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An Efficient Synthesis of Chiral Alcohols via Catalytic Hydrogenation of Esters

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Abstract

A ruthenium complex was found to catalyze the hydrogenation of chiral esters without the loss of their optical purities under mild and neutral conditions. This method can avoid a violent quench step and an extraction step which accompany conventional reduction using metal hydride reagents such as sodium borohydride and lithium aluminum hydride.

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Notes

  1. 1.

    Within our research, THF solvent performed better than other solvents. In addition, other types of esters such as isopropyl ester, benzyl ester and phenyl ester were not hydrogenated as effectively as methyl ester (Unpublished data)

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Correspondence to Yasunori Ino.

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Ino, Y., Kuriyama, W., Ogata, O. et al. An Efficient Synthesis of Chiral Alcohols via Catalytic Hydrogenation of Esters. Top Catal 53, 1019–1024 (2010). https://doi.org/10.1007/s11244-010-9573-x

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Keywords

  • Ester
  • Hydrogenation
  • Homogeneous
  • Ruthenium
  • Catalyst
  • Chiral
  • Alcohol
  • Amino alcohol
  • Diol