Topics in Catalysis

, Volume 35, Issue 1–2, pp 117–130

Enantioselective Biotransformations of Nitriles in Organic Synthesis

Article

DOI: 10.1007/s11244-005-3817-1

Cite this article as:
Wang, MX. Top Catal (2005) 35: 117. doi:10.1007/s11244-005-3817-1

Abstract

Recent advances in enantioselective biotransformations of nitriles utilizing nitrile-hydrolyzing microorganisms and enzymes are summarized in this article. Various examples of biocatalytic synthesis of highly enantiopure carboxylic acids including amino acids, hydroxyl acids, cyclopropanecarboxylic acids and amide derivatives and oxiranecarboxamides are presented. The enantioselectivity of the nitrile hydratases, nitrilases and amideses is discussed.

Keywords

Biotransformations nitrile hydratase nitrilase amidese nitrile carboxylic acid carboxamide amino acid hydroxyl acid cyclopropanecarboxylic acid oxiranecarboxamide desymmetrization 

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  1. 1.Laboratory of Chemical Biology, Center for Molecular Science, Institute of ChemistryChinese Academy of SciencesBeijingChina

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