Enantioselective Biotransformations of Nitriles in Organic Synthesis
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- Wang, MX. Top Catal (2005) 35: 117. doi:10.1007/s11244-005-3817-1
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Recent advances in enantioselective biotransformations of nitriles utilizing nitrile-hydrolyzing microorganisms and enzymes are summarized in this article. Various examples of biocatalytic synthesis of highly enantiopure carboxylic acids including amino acids, hydroxyl acids, cyclopropanecarboxylic acids and amide derivatives and oxiranecarboxamides are presented. The enantioselectivity of the nitrile hydratases, nitrilases and amideses is discussed.
KeywordsBiotransformations nitrile hydratase nitrilase amidese nitrile carboxylic acid carboxamide amino acid hydroxyl acid cyclopropanecarboxylic acid oxiranecarboxamide desymmetrization
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