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Anticancer activities of manganese-based photoactivatable CO-releasing complexes (PhotoCORMs) with benzimidazole derivative ligands

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Abstract

Carbon monoxide is an important signaling molecule which is produced by heme oxygenase-1. CO shows antiproliferative activity against cancer cells; hence, activation of HO-1 is a significant inhibition strategy against tumor formation and survival of cancer cells. In this work, manganese-based CO-releasing molecules (CORMs) were designed and synthesized to inhibit breast cancer cell proliferation. Human invasive ductal breast cancer cells (MCF-7) were treated with the synthesized CORMs to investigate the effect of the complexes on breast cancer survival under UV light. In vitro experiments indicated that the complexes inhibited breast cancer cell proliferation, and further, the antiproliferative effects were increased under UV light. Thus, these novel CORMs may provide a drug template for the treatment of invasive ductal breast cancer.

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Acknowledgements

This work by Scientific and Technological Research Council of Turkey (TÜBİTAK, Project No: 112T320) is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Art and Science, Ordu University, 52200, Ordu, Turkey

    Elvan Üstün

  2. Department of Bioengineering, Faculty of Natural Sciences and Engineering, Gaziosmanpaşa University, 60100, Tokat, Turkey

    Aykut Özgür & Kübra A. Coşkun

  3. Department of Chemistry, Faculty of Science, İnönü University, 44280, Malatya, Turkey

    Serpil Demir Düşünceli & İsmail Özdemir

  4. Division of Biochemistry, Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Cumhuriyet University, 58140, Sivas, Turkey

    Yusuf Tutar

Authors
  1. Elvan Üstün
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  2. Aykut Özgür
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  3. Kübra A. Coşkun
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  4. Serpil Demir Düşünceli
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  5. İsmail Özdemir
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Correspondence to Elvan Üstün.

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Üstün, E., Özgür, A., Coşkun, K.A. et al. Anticancer activities of manganese-based photoactivatable CO-releasing complexes (PhotoCORMs) with benzimidazole derivative ligands. Transit Met Chem 42, 331–337 (2017). https://doi.org/10.1007/s11243-017-0136-x

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  • DOI: https://doi.org/10.1007/s11243-017-0136-x

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