Transition Metal Chemistry

, Volume 41, Issue 7, pp 775–781 | Cite as

Synthesis of a palladium(II) complex of a N-heterocylic carbene via transmetalation: crystal structure and antibacterial studies

  • Rosenani A. Haque
  • Umie F. M. Haziz
  • A. A. Amirul
  • Noor Shaheeda
  • Mohd R. Razali


An Ag(I)-N-heterocylic carbene (NHC) complex, [Ag(L)2]PF6 (L = 1-(2′-methylbenzyl)-3-(2″-propyl)benzimidazolium), was used as a transfer agent for the synthesis of a Pd(II)–NHC complex, formulated as [PdCl(L)2(MeCN)]PF6 (Pd1). The complex Pd1 was characterized by 1H and 13C NMR, FTIR spectroscopy and elemental analysis. Single crystal X-ray diffraction analysis reveals that the Pd(II) atom has a square planar geometry. This complex was screened for its antibacterial potential against the Gram-negative bacteria Escherichia coli (ATCC 25922) and the Gram-positive bacteria Staphylococcus aureus (ATCC 12600). These results are compared with those obtained for a standard antibiotic, ampicillin, and also the corresponding Ag(I)–NHC complex.


Minimum Inhibitory Concentration Carbene Benzimidazolium Disc Diffusion Method Minimum Bactericidal Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the RUI Grant 1001/PKIMIA/811260.

Supplementary material

11243_2016_78_MOESM1_ESM.doc (1.5 mb)
Supplementary material 1 (DOC 1559 kb)


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Rosenani A. Haque
    • 1
  • Umie F. M. Haziz
    • 1
  • A. A. Amirul
    • 2
    • 3
  • Noor Shaheeda
    • 2
  • Mohd R. Razali
    • 1
  1. 1.School of Chemical SciencesUniversiti Sains Malaysia (USM)GelugorMalaysia
  2. 2.School of Biological SciencesUniversiti Sains Malaysia (USM)GelugorMalaysia
  3. 3.Centre of Chemical BiologyUniversiti Sains MalaysiaGelugorMalaysia

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