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Transition Metal Chemistry

, Volume 40, Issue 2, pp 179–187 | Cite as

Synthesis, characterization and anticancer activity of 3-formylchromone benzoylhydrazone metal complexes

  • Shadia A. Elsayed
  • Ian S. Butler
  • Betrand Jean Claude
  • Sahar I. Mostafa
Article

Abstract

A new Schiff base derived from 3-formylchromone and benzohydrazide (Hfcbh) and its Ni(II), Zn(II), Ru(II), Ru(III), Pd(II), Pt(II) and Ag(I) complexes were synthesized. These compounds were characterized on the basis of physicochemical and spectroscopic methods. Two modes of chelation for Hfcbh are reported: (1) neutral tridentate ligand through the chromone carbonyl oxygen, hydrazonic carbonyl oxygen and azomethine nitrogen atoms and (2) mononegative tridentate ligand via the chromone carbonyl oxygen, hydrazonic deprotonated hydroxy oxygen and azomethine nitrogen atoms. Free Hfcbh and its Ni(II), Zn(II), Ag(I), Pd(II) and Pt(II) complexes have been tested as anticancer agents against the human breast cancer (MDA-MB231) and human ovarian cancer (OVCAR-8) cell lines. The [Ag(fcbh)(PPh3)] complex shows the highest efficacy with a mean IC50 values of 1.0 (MDA-MB231) and 0.87 (OVCAR-8) µM, respectively.

Keywords

Human Breast Cancer PPh3 Human Ovarian Cancer Chromone Pyrone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of ScienceDamietta UniversityNew DamiettaEgypt
  2. 2.Department of ChemistryMcGill UniversityMontrealCanada
  3. 3.Department of Medicine, Royal Victoria HospitalMcGill UniversityMontrealCanada
  4. 4.Chemistry Department, Faculty of ScienceMansoura UniversityMansouraEgypt

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