Transition Metal Chemistry

, Volume 38, Issue 3, pp 291–298 | Cite as

Synthesis, DNA binding, antioxidant and cytotoxic activities of ruthenium(II) complexes of a Schiff base ligand

  • Subbaiyan Sathiyaraj
  • Krishnan Sampath
  • Ray J. Butcher
  • Chinnasamy Jayabalakrishnan
Article
First Online:
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Accepted:

Abstract

Three ruthenium(II) complexes, [Ru(CO)Cl(PPh3)L], [Ru(CO)Cl(AsPh3)L] and [Ru(CO)Cl(Py)L], were synthesized from the reactions of 2-(benzothiazol-2-yliminomethyl)-phenol (HL) with [RuHCl(CO)B(EPh3)2], where B = PPh3, AsPh3 or pyridine, and E = P or As. All the complexes have been characterized by physicochemical and spectroscopic methods. The structure of the free ligand HL was determined by single crystal X-ray diffraction. The binding of the free ligand and its complexes with CT-DNA was studied using electronic absorption spectroscopy. In addition, the free ligand and its complexes were subjected to antioxidant activity tests, which showed that they all possess significant scavenging effects against DPPH and OH radicals. The in vitro cytotoxicities of the compounds were assessed using tumor (HeLa and MCF-7) cell lines.

Keywords

DPPH Ruthenium Schiff Base PPh3 Radical Scavenge Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgments

We sincerely thank University Grants Commission (UGC), New Delhi, for financial support [MRP Scheme. No. 38-222/2009 (SR)].

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Subbaiyan Sathiyaraj
    • 1
  • Krishnan Sampath
    • 1
  • Ray J. Butcher
    • 2
  • Chinnasamy Jayabalakrishnan
    • 1
  1. 1.Post Graduate and Research Department of ChemistrySri Ramakrishna Mission Vidyalaya College of Arts and ScienceCoimbatoreIndia
  2. 2.Department of ChemistryHoward UniversityWashingtonUSA

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