Three ruthenium(II) complexes, [Ru(CO)Cl(PPh3)L], [Ru(CO)Cl(AsPh3)L] and [Ru(CO)Cl(Py)L], were synthesized from the reactions of 2-(benzothiazol-2-yliminomethyl)-phenol (HL) with [RuHCl(CO)B(EPh3)2], where B = PPh3, AsPh3 or pyridine, and E = P or As. All the complexes have been characterized by physicochemical and spectroscopic methods. The structure of the free ligand HL was determined by single crystal X-ray diffraction. The binding of the free ligand and its complexes with CT-DNA was studied using electronic absorption spectroscopy. In addition, the free ligand and its complexes were subjected to antioxidant activity tests, which showed that they all possess significant scavenging effects against DPPH and OH radicals. The in vitro cytotoxicities of the compounds were assessed using tumor (HeLa and MCF-7) cell lines.
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Tolomeo M, Simoni D (2002) Curr Med Chem Anti Cancer Agents 2:387
Coury JE, Anderson JR, Isom LM, Williams LD, Bottomley LA (1997) J Am Chem Soc 119:3792
Trynda-Lemiesz L (2004) Acta Biochim 52(1):199
Bergamo A, Stocco G, Casassa C, Cocchettio M, Alessio E, Serli B, Zorzet S, Sava G (2004) Int J Oncol 24:373
Mann J, Baron A, Opoku-Boahen Y, Johansson E, Parkinson G, Kelland LR, Neidle S (2001) J Med Chem 44:138
Chua MS, Kachiyama E, Bradshaw TD, Stinson SF, Brantly E, Sausille EA, Stevens MFB (2000) Cancer Res 60:5196
Vogal AI (1989) Text book of practical organic chemistry, 5th edn. Longman, London
Ahmed N, Levison JJ, Robinson SD, Uttley MF (1974) Inorg Synth 15:48
Sanchez-Delgade RA, Lee WY, Choi SR, Cho YMJ, Jun Y (1991) Trans Met Chem 16:41
Gopinathan S, Unny IR, Deshpande SS, Gopinathan C (1986) Ind J Chem A 25:1015
Sheldrick GM, SHELXS-97, SHELX-97 (1997) Fortran programs for crystal structure solution and refinement. University of Gottingen, Germany
Wolf A, Shimer GH, Meehan T (1987) Biochem 26:6392
Elizabeth K, Rao MNA (1990) Int J Pharmaceut 58:237
Yu W, Zhao Y, Shu B (2004) Food Chem 86:525
Blagosklonny M, EL-Diery WS (1996) Int J Cancer 67:386
Ramesh R, Sivagamasundari M (2003) Synth React Inorg Met-Org Chem 33:899
Nakamoto K (1971) Infrared and Raman spectra of inorganic and co-ordination compounds. Wiley Interscience, New York
Das AK, Peng SM, Bhattacharya SJ (1976) Chem Soc Jpn 49:287
Sharma RK, Singh RV, Tandon JPJ (1980) Inorg Nucl Chem 42:1382
Natarajan K, Poddar RK, Agarwala CJ (1977) Inorg Nucl Chem 39:431
Lever ABP (1984) Inorganic electronic spectroscopy, 2nd edn. Elsevier, New York
Maji M, Ghosh S, Chattopaghyay SK, Mak TCW (1997) Inorg Chem 36:2938
Singh RV, Joshi SC, Gajraj A, Nagpal P (2002) Appl Organomet Chem 16:713
Navarro M, Cisneros-Fajardo EJ, Sierralta A, Fernández-Mestre M, Silva P, Arrieche D, Marchán E (2003) J Biol Inorg Chem 8:401
Perz S, Lopez C, Caubet A, Solans X, Bardia MF, Gich M, Molins E (2007) J Organomet Chem 692:2402
Shankera K, Rohinia R, Ravindera V, Reddy PM, Ho Y-P (2009) Spectrochim. Acta A 73:205
Desbosis MH, Astruc D (1989) Organometallics 8:1841
Karvembu R, Natarajan K (2002) Polyhedron 21:1721
Long EC, Barton JK (1990) Acc Chem Res 23:271
Chitrapriya N, Mahalingam V, Zeller M, Natarajan K (2010) Inorg Chim Acta 363:3685
Liu XW, Li J, Deng H, Zheng KC, Mao ZW, Ji LN (2005) Inorg Chim Acta 358:3311
Liang ZH, Li ZZ, Huang HL, Liu YJ (2011) J Coord Chem 64:3342
We sincerely thank University Grants Commission (UGC), New Delhi, for financial support [MRP Scheme. No. 38-222/2009 (SR)].
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Sathiyaraj, S., Sampath, K., Butcher, R.J. et al. Synthesis, DNA binding, antioxidant and cytotoxic activities of ruthenium(II) complexes of a Schiff base ligand. Transition Met Chem 38, 291–298 (2013). https://doi.org/10.1007/s11243-013-9690-z
- Schiff Base
- Radical Scavenge Activity