Transition Metal Chemistry

, Volume 37, Issue 4, pp 337–344 | Cite as

Kinetic studies on H+-catalysed aquation of chromium(III)-oxalato-asparaginato and chromium(III)-oxalato-histidinato complexes

  • Hasan Marai
  • Ewa Kita
  • Emilia Kiersikowska
  • Sylwia Kuchta
  • Anna Bajek
  • Tomasz Drewa
Article

Abstract

Three chromium(III) complexes with asparagine (Asn) and histidine (His) of the [Cr(ox)2(Aa)]2− type, where Aa = N,O–Asn, N,O–His or N,N′–His, were obtained and characterized in solution. The complexes with N,O–Aa undergo acid-catalysed aquation to give a free amino acid and cis-[Cr(ox)2(H2O)2], whereas the complex with N,N′–His undergoes parallel reaction paths: (1) isomerization to the N,O–His complex and (2) liberation of an oxalate ligand. Kinetics of the N,O–Aa complexes in HClO4 media were studied spectrophotometrically under pseudo-first-order conditions. The absorbance changes were attributed to the chelate ring opening at the Cr–N bond. The linear dependence of rate constants on [H+] was established, and a mechanism for the chelate ring cleavage was postulated. The existence of a metastable intermediate with O-monodentate Aa ligand was proved experimentally. Effect of [Cr(ox)2(Aa)]2− on 3T3 fibroblasts proliferation was studied. The tests revealed low cytotoxicity of the complexes. Complexes with Ala, His and Cys are good candidates for biochromium sources.

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Hasan Marai
    • 1
  • Ewa Kita
    • 1
  • Emilia Kiersikowska
    • 1
  • Sylwia Kuchta
    • 1
  • Anna Bajek
    • 2
  • Tomasz Drewa
    • 2
  1. 1.Faculty of ChemistryN. Copernicus UniversityToruńPoland
  2. 2.Department of Tissue EngineeringN. Copernicus UniversityBydgoszczPoland

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