Transition Metal Chemistry

, 36:679 | Cite as

Synthesis, characterization and antimicrobial activity of 3,5-di-tert-butylsalicylaldehyde-S-methylthiosemicarbazones and their Ni(II) complexes

  • Baki Türkkan
  • Bahtiyar Sarıboğa
  • Nezaket Sarıboğa
Article
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Abstract

Ni(II) complexes were prepared by the reactions of 3,5-di-tert-butylsalicylaldehyde-S-methylisothiosemicarbazone (L) with salicylaldehyde or 2-hydroxy-1-naphthaldehyde in the presence of NiCl2·6H2O. The complexes and starting material L were characterized by physic-chemical analysis and spectroscopic techniques such as 1HNMR, 13CNMR, IR and UV–VIS. Antimicrobial activity studies of L and the two complexes standards strains of bacteria (Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Bacillus cereus, Enterococcus faecalis, Streptococcus pneumoniae, Listeria monocytogenes, Escherichia coli, Salmonella typhi and Candida albicans) and 22 clinically isolated microorganisms, including multidrug resistant pathogenic microorganisms, were carried out. The free thiosemicarbazone L showed a significant inhibition of the growth all of Gram-positive bacteria tested.

Keywords

Minimum Inhibitory Concentration Salicylaldehyde Thiosemicarbazide Standard Strain Azomethine Nitrogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgments

This work was supported by the Research Fund of the University of Nevşehir.

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Baki Türkkan
    • 1
  • Bahtiyar Sarıboğa
    • 2
  • Nezaket Sarıboğa
    • 2
  1. 1.Department of ChemistryHarran UniversityOsmanbeyTurkey
  2. 2.Department of ChemistryNevşehir UniversityNevsehirTurkey

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