Transition Metal Chemistry

, Volume 36, Issue 5, pp 505–512

Synthesis, characterization, and antibacterial activities of copper(I) bromide complexes of thioureas: X-ray structure of [Cu(Metu)4]Br

  • Muhammad Mufakkar
  • Anvarhusein A. Isab
  • Tobias Rüffer
  • Heinrich Lang
  • Saeed Ahmad
  • Najma Arshad
  • Abdul Waheed
Article

DOI: 10.1007/s11243-011-9496-9

Cite this article as:
Mufakkar, M., Isab, A.A., Rüffer, T. et al. Transition Met Chem (2011) 36: 505. doi:10.1007/s11243-011-9496-9

Abstract

Copper(I) complexes of thioureas having the general formulae [CuLnBr] and [CuLn]Br [where, n = 1 − 4 and L = thiourea (Tu), N-methylthiourea (Metu), N-ethylthiourea (Ettu), N,N-dipropylthiourea (Dprtu), N,N-dibutylthiourea (Dbtu) or N,N-diphenylthiourea (Dphtu)] were prepared and characterized by elemental analysis, IR, and NMR (1H and 13C) spectroscopy. The crystal structure of one of them, [Cu(Metu)4]Br (1), was determined by X-ray crystallography. The X-ray structure of 1 describes a tetrahedral geometry around copper(I) with all Metu ligands binding through sulfur atoms. An upfield shift in the 13C NMR and downfield shift in the 1H NMR spectra are consistent with the thione coordination to copper(I). Antimicrobial activities of the complexes were evaluated by the minimum inhibitory concentration method. The results showed that only [Cu(Ettu)3Br] was effective in inhibiting the growth of all the tested organisms (gram-positive, gram-negative bacteria, and Candida sp.), while the other complexes were not effective against all the organisms.

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Muhammad Mufakkar
    • 1
  • Anvarhusein A. Isab
    • 2
  • Tobias Rüffer
    • 3
  • Heinrich Lang
    • 3
  • Saeed Ahmad
    • 4
  • Najma Arshad
    • 5
  • Abdul Waheed
    • 1
  1. 1.Department of ChemistryGovernment College UniversityLahorePakistan
  2. 2.Department of ChemistryKing Fahd University of Petroleum and MineralsDhahranSaudi Arabia
  3. 3.Lehrstuhl für Anorganische Chemie, Institut für ChemieTechnische Universität ChemnitzChemnitzGermany
  4. 4.Department of ChemistryUniversity of Engineering and TechnologyLahorePakistan
  5. 5.Department of ZoologyUniversity of the PunjabLahorePakistan

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