Transition Metal Chemistry

, Volume 35, Issue 6, pp 649–658 | Cite as

Interaction of E. coli DNA with diazine-bridged late first row transition metal complexes derived from hexadentate compartmental ligands: an approach to DNA cleavage/binding studies

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Abstract

A series of binuclear CoII, NiII, CuII and ZnII complexes having μ-1,2 diazine bridging have been prepared and characterized by various physico-chemical methods. The hexadentate ligands were synthesized by condensing 3,5-dichloroformyl-1H-pyrazole with 2-hydrazinobenzothiazole (L1H) or 4-aminoantipyrine (L2H) in 1:2 ratio. Gel electrophoresis data indicate cleavage of E. coli DNA to a minute extent by both [Co2L2(μ-Cl)Cl2(H2O)2]·H2O and [Ni2L2(μ-Cl)Cl2(H2O)2]. Conversely, the data for the remaining complexes indicated binding but not cleavage. These results were confirmed by viscosity measurements and absorption spectral studies. An intercalative binding mode is predicted when the title complexes interact with DNA.

Keywords

Pyrazole Antipyrine Benzothiazole Pyrazole Ring TCNE 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgments

The authors thank the USIC and Department of Chemistry, Karnatak University, Dharwad, for providing spectral facility. Recording of FAB mass spectra (CDRI Lucknow) and ESR spectra (IIT Bombay) is gratefully acknowledged. One of the author thanks (Srinivasa Budagumpi) UGC for awarding Research Fellowship in Science for Meritorious Students.

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Department of ChemistryKarnatak UniversityDharwadIndia

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