A mixed ligand coordination compound of copper with ofloxacin (oflo) and phenanthroline (phen) has been synthesized and characterized by means of X-ray single crystal diffraction and spectroscopic methods. Structural features of the coordination compound are described. CD and CV studies of the interactions of the title complex with calf thymus DNA (CT-DNA) show that the complex can bind to CT-DNA by intercalation and electrostatic binding modes. Antibacterial activities of the title compound, a Cu–oflo complex reported earlier and free oflo have been studied against different microorganisms. Both copper complexes enhance the antibacterial activities of the quinolone drugs. The inhibitory effect of the three compounds on two cancer cell lines was measured and the results indicate that the title complex has strongest inhibitory effect.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Chan S, Wong WT (1995) Coord Chem Rev 138:219–296
Afrasiabi Z, Sinn E, Padhye S, Dutta S, Newton C, Anson CE, Powell AK (2003) J Inorg Biochem 95:306–314
Sigman DS, Graham DR, Aurora VD, Stern AM (1979) J Biol Chem 254:12269–12272
Mitscher LA (2005) Chem Rev 105:559–592
Turel I, Leban I, Bukovec N (1994) J Inorg Biochem 56:273–282
Turel I, Golic L, Ruiz Ramirez OL (1999) Acta Chim Slov 46:203–211
Aleixandre V, Herrera G, Urios A, Blanco M (1991) Antimicrob Agents Chemother 35:20–23
Macias B, Villa MV, Rubio I, Castineiras A, Borras J (2001) J Inorg Biochem 84:163–170
Gameiroa P, Rodriguesb C, Baptistab T, Sousaa I, Castroa B (2007) Int J Pharm 334:129–136
Tselepi-Kalouli E, Katsaros N (1989) J Inorg Biochem 37:271–282
Sheldrick M (1998) SHELX-97, programs for crystal structure analysis. University of Gottingen, Gottingen, Germany, pp 97–98
Golobic T, Klavzar A, Philar B, Buglyo P, Tolis E, Rehder D, Sepcic K (2003) J Inorg Biochem 95:199–207
Deacon GB, Phillips RJ (1980) Coord Chem Rev 33:227–250
Dendrinou-Samara C, Tsotsou G, Raptopoulou CP, Kortsaris A, Kyriakidis D, Kessissoglou DP (1998) J Inorg Biochem 71:171–179
Sorenson JRJ (1989) Prog Med Chem 26:437–586
Saha DK, Sandbhor U, Shirisha K, Padhye S, Deobagkar D, Ansond CE, Powell AK (2004) Bioorg Med Chem Lett 14:3027–3032
King DE, Malone R, Lilley SH (2000) Am Fam Physician 61:2741–2748
Prabhakan B, Lengaiah P, Reddy KL (1990) Polyhedron 9:805–811
Kwaiatkowski M, Kwaiatkowski E, Olechnowicz A, Bandol G (1991) Inorg Chim Acta 182:117–127
Mendoza-Diaz G, Martinez-Aguilera LMR, Perez-Alonso R, Solans X, Moreno-Espanza R (1993) Inorg Chim Acta 211:133–139
Mendoza-Diaz G, Martinez-Auguilera LMR, Moreno-Esparza R, Pannell KH, Cervantes-Lee F (1993) J Inorg Biochem 50:65–78
Psomas G, Raptopoulou CP, Iordanidis L, Dendrinou-Samara C, Tangoulis V, Kessissoglou DP (2000) Inorg Chem 39:3042–3048
Dendrinou-Samara C, Psomas G, Raptopoulou CP, Kessissoglou DP (2001) J Inorg Biochem 83:7–16
Saha DK, Sandbhor U, Shirisha K, Padhye S, Deobagkar D, Anson CE, Powell AK (2004) Med Chem Lett 14:3027–3032
Song G, He Y, Cai Z (2004) J Fluoresc 14:705–710
Rodoriguez M, Bard AJ (1990) Anal Chem 62:2658–2662
Millian KM, Mikkelsen SR (1993) Anal Chem 65:2317–2323
Maheswari PU, Palaniandavar MJ (2004) Inorg Biochem 98:219–230
Song YM, Kang JW, Gao JZ, Feng YF (2000) Chin J Inorg Chem 16:53–57
Krivis AF, Rabb JM (1996) Science 164:1064–1065
Wang GP, Zhu LG, Yu QS (2003) Chin J Inorg Chem 19:179–182
Chang-Yun Chen and Quan-Zhan Chen contributed equally to this work.
About this article
Cite this article
Chen, C., Chen, Q., Wang, X. et al. Synthesis, characterization, DNA binding properties, and biological activities of a mixed ligand copper(II) complex of ofloxacin. Transition Met Chem 34, 757–763 (2009). https://doi.org/10.1007/s11243-009-9259-z
- Antitumour Activity
- A549 Cell Line
- Title Complex