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Synthesis, crystal structures, and catalytic hydrolysis activities of four dinuclear complexes with 1,4,7,10-tetraazacyclododecane and succinate ligands

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Four new dinuclear complexes of the type [M2(cyclen)2(suc)]Cl2 · nH2O (M = Co2+, Ni2+, Cu2+, Zn2+, cyclen = 1,4,7,10-tetraazacyclododecane, suc = succinate) have been obtained by the reaction of cyclen and succinate with the corresponding metal dichlorides in aqueous solution. All the complexes were characterized by physico-chemical and spectroscopic methods. The crystal structure of [Ni2(cyclen)2(suc)]Cl2 · 2H2O was determined. The four complexes have similar compositions and structures and are all bridged by succinate. Furthermore, the hydrolysis of bis(2,4-dinitrophenyl)phosphate (BDNPP) promoted by the four complexes was studied. The experimental results indicate that these complexes can efficiently catalyze hydrolysis of BDNPP, and their catalytic activities are in the order Ni > Zn > Cu > Co.

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  1. 1.

    Liu C, Wang M, Zhang T, Sun H (2004) Coord Chem Rev 248:147. doi:10.1016/j.cct.2003.11.002

  2. 2.

    Burger RM (1998) Chem Rev 98:1153. doi:10.1021/cr960438a

  3. 3.

    Armitage B (1998) Chem Rev 98:1171. doi:10.1021/cr960428+

  4. 4.

    Sheng X, Guo X, Lu XM, Lu GY, Shao Y, Liu F, Xu Q (2008) Bioconj Chem 19:490. doi:10.1021/bc700322w

  5. 5.

    Morrow JR, Iranzo O (2004) Curr Opin Chem Biol 8:192. doi:10.1016/j.cbpa.2004.02.006

  6. 6.

    Corneillie TM, Whetstone PA, Lee KC, Wong JP, Meares CF (2004) Bioconj Chem 15:1389. doi:10.1021/bc049825e

  7. 7.

    Boseggia E, Gatos M, Lucatello L, Mancin F, Moro S, Palumbo M, Sissi C, Tecilla P, Tonellato U, Zagotto G (2004) J Am Chem Soc 126:4543. doi:10.1021/ja039465q

  8. 8.

    An Y, Tong ML, Ji NL, Mao ZW (2006) Dalton Trans 2066. doi:10.1039/b516132k

  9. 9.

    Jin Y, Cowan JA (2005) J Am Chem Soc 127:8408. doi:10.1021/ja0503985

  10. 10.

    Rey NA, Neves A, Bortoluzzi AJ, Pich CT, Terenzi H (2007) Inorg Chem 46:348. doi:10.1021/ic0613107

  11. 11.

    Young MJ, Chin J (1995) J Am Chem Soc 117:10577. doi:10.1021/ja00147a022

  12. 12.

    Ren YW, Wang C, Li J, Zhang FX (2006) Transit Met Chem 31:611. doi:10.1007/s11243-006-0037-x

  13. 13.

    Iranzo O, Elmer T, Richard JP, Morrow JR (2003) Inorg Chem 42:7737. doi:10.1021/ic030131b

  14. 14.

    Beese LS, Steitz TA (1991) EMBO J 10:25

  15. 15.

    Davies JF, Hostomska Z, Hostomsky Z, Jordan SR, Matthews DA (1991) Science 252:88. doi:10.1126/science.1707186

  16. 16.

    Lahm A, Volbeda S, Suck D (1990) J Mol Biol 215:207. doi:10.1016/S0022-2836(05)80337-7

  17. 17.

    Kim EE, Wyckoff HW (1991) J Mol Biol 218:449. doi:10.1016/0022-2836(91)90724-K

  18. 18.

    Hough E, Hansen LK, Birknes B, Jynge K, Hansen S, Hordvik A, Little C, Dodson EJ, Derewenda Z (1989) Nature 338:357. doi:10.1038/338357a0

  19. 19.

    Branum ME, Tipton AK, Que LJ (2001) J Am Chem Soc 123:1898. doi:10.1021/ja0010103

  20. 20.

    Eric LH, Judith NB (1998) Coord Chem Rev 173:133. doi:10.1016/S0010-8545(98)00157-X

  21. 21.

    Kimura E, Shin AT, Koike MS (1997) J Am Chem Soc 119:3068. doi:10.1021/ja9640408

  22. 22.

    Aoki S, Kimura E (2004) Chem Rev 104:767. doi:10.1021/cr020617u

  23. 23.

    Ye BH, Tong ML, Chen XM (2005) Coord Chem Rev 249:545. doi:10.1016/j.ccr.2004.07.006

  24. 24.

    Richman JE, Atkins TJ (1974) J Am Chem Soc 96:2268. doi:10.1021/ja00814a056

  25. 25.

    Bunton CA, Farber SJ (1969) J Org Chem 34:767. doi:10.1021/jo01256a001

  26. 26.

    Sheldrick GM (1997) SHELXL97, program for the refinement of crystal structure. University of Gottingen, Germany

  27. 27.

    Zhou CQ, Gao F, Li SE, Yang P (2003) J Chin Rare Earth Soc 21:499

  28. 28.

    Snned M, Maynard (1942) General inorganic chemistry. Van Nostrand, New York, p 813

  29. 29.

    Dong QG (2001) Spectrum principle and resolution. Science Press, Beijing, pp 98–99

  30. 30.

    Nakamoto K (1986) Infrared and Raman spectra of inorganic and coordination compounds, 1st edn (trans: Huang DR, Wang RQ). Chemical Industry Press, Beijing, pp 234–241(in Chinese)

  31. 31.

    Gu GB, Liu HB (2003) Acta Chim Sin 61:1592

  32. 32.

    Li J, Ren YW, Zhang JH, Yang P (2004) J Chem Crystallogr 34:409. doi:10.1023/B:JOCC.0000035380.06741.4e

  33. 33.

    Ren YW, Wu AZ, Li J (2005) Chin J Chem 23:132. doi:10.1002/cjoc.200590132

  34. 34.

    Kenneth AB, Thomas CB (1992) J Am Chem Soc 114:4951. doi:10.1021/ja00039a001

  35. 35.

    Rossi LM, Neves A, Bortoluzzi AJ, Hörner R, Szpoganicz B, Terenzi H, Mangrich AS, Pereira-Maia E, Castellano EE, Haase W (2005) Inorg Chim Acta 358(6):1807. doi:10.1016/j.ica.2004.10.027

  36. 36.

    Longhinotti E, Domingos JB, Szpoganicz B, Neves A, Nome F (2005) Inorg Chim Acta 358:2089. doi:10.1016/j.ica.2004.12.052

  37. 37.

    Greatti A, Scarpellini M, Peralta RA, Casellato A, Bortoluzzi AJ, Xavier FR, Jovito R, Brito MA, Szpoganicz B, Tomkowicz Z, Rams M, Haase W, Neves A (2008) Inorg Chem 47(3):1107–1119. doi:10.1021/ic702132t

  38. 38.

    Yang P, Zhou CQ (2003) Acta Chim Sin 361(9):1455

  39. 39.

    Lanznaster M, Neves A, Bortoluzzi AJ, Aires VVE, Szpoganicz B, Terenzi H, Severino PC, Fuller JM, Drew SC, Gahan LR, Hanson GR, Riley MJ, Schenk G (2005) J Biol Inorg Chem 10(4):319. doi:10.1007/s00775-005-0635-7

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This work was supported by the State Key Laboratory of Fine Chemicals and The Educational Committee Foundation of Shaanxi Province.

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Correspondence to Jun Li.

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Yang, G., Li, J., Ren, Y. et al. Synthesis, crystal structures, and catalytic hydrolysis activities of four dinuclear complexes with 1,4,7,10-tetraazacyclododecane and succinate ligands. Transition Met Chem 34, 191–196 (2009). https://doi.org/10.1007/s11243-008-9178-4

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  • Succinate
  • Cyclen
  • Dinuclear Complex
  • Phosphate Diester
  • Artificial Nuclease