Transition Metal Chemistry

, Volume 33, Issue 8, pp 981–988 | Cite as

Thermodynamic quantities for the oxidation of ranitidine by diperiodatocuprate(III) in aqueous alkaline medium

  • T. M. Veeresh
  • R. K. Patil
  • Sharanappa T. Nandibewoor
Article
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Accepted:

Abstract

The kinetics of oxidation of the anti-ulcer drug, ranitidine hydrochloride (RNH) by diperiodatocuprate(III) (DPC) in alkaline medium was studied spectrophotometrically. The reaction exhibits 1:2 stoichiometry (ranitidine:DPC). The reaction is of first order in [DPC] and has less than unit order in [RNH] and negative fractional order in [alkali]. The involvement of free radicals was observed in the reaction. The oxidation has been found to proceed via a DPC-ranitidine complex, which decomposes slowly in a rate-determining step followed by other fast steps to give the products, which were identified as ranitidine sulfoxide by spot test and spectroscopic studies.

Keywords

Ranitidine Periodate Unit Order Slow Step KIO4 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Supplementary material

11243_2008_9140_MOESM1_ESM.doc (494 kb)
(DOC 495 kb)

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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • T. M. Veeresh
    • 1
  • R. K. Patil
    • 1
  • Sharanappa T. Nandibewoor
    • 1
  1. 1.P.G. Department of Studies in ChemistryKarnatak UniversityDharwadIndia

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