Transition Metal Chemistry

, Volume 31, Issue 4, pp 441–446 | Cite as

Synthesis, Characterization, Electrochemical Properties and Antibacterial Activity of Some Transiton Metal Complexes with [(2-hydroxy-1-naphthaldehyde)-3-isatin]-bishydrazone

  • Balakrishnan Murukan
  • Kochukittan MohananEmail author


A bishydrazone was prepared by reacting isatin monohydrazone with 2-hydroxy-1-naphthaldehyde and a series of metal complexes with this new ligand were synthesised by reaction with MnII, FeII, CoII, NiII, CuII and ZnII salts. The complexes were characterised on the basis of elemental analysis, molar conductance, magnetic susceptibility data, u.v.–visible, i.r., e.s.r. and n.m.r. spectral studies, wherever possible and applicable. Analytical data reveal that the nickel(II), copper(II) and zinc(II) complexes possess 1:1 metal–ligand ratios and that manganese(II), iron(II) and cobalt (II) complexes exhibit 1:2 ratios. Infrared spectral data suggest that the bishydrazone behaves as a monobasic tridentate ligand with ONO donor sequence towards the metal ions. X-ray diffraction study of the copper(II) complex indicated an orthorhombic crystal lattice. The e.p.r. spectral data show that the metal–ligand bond has considerable covalent character. The electrochemical behaviour of the copper(II) complex was investigated by cyclic voltammetry (CV). Antibacterial tests of the ligand and the metal complexes were also carried out and it has been observed that the complexes are more potent bactericides than the ligand.


Magnetic Susceptibility Metal Complex Isatin Molar Conductance Covalent Character 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Katyal, M., McBryde, W.A.E. 1978Technical News Service, Part I & IISarabai M. ChemicalsBarodaGoogle Scholar
  2. 2.
    Maria, C.R., Marisa, B.F., Franco, B., Corrado, P., Giorgio, P., Silvana,  P., Monica, S. 2004J. Inorg. Biochem.98313CrossRefGoogle Scholar
  3. 3.
    Hassan, M.A. 1997Ind. J. Chem.36241Google Scholar
  4. 4.
    Seshaiah, K.S., Atmakuru, R. 2001Biol. Pharm. Bull.241149CrossRefGoogle Scholar
  5. 5.
    Pandeya, S.N., Smitha, S., Jyoti, M., Sridhar, S.K. 2005Acta Pharm.5527Google Scholar
  6. 6.
    Seshaiah, K.S., Surendra, N.P., James, P.S., Atmakuru, R. 2002Eur. J. Pharm. Sci.16129CrossRefGoogle Scholar
  7. 7.
    Offiong, E.O., Martelli, S. 1994IL Farmaco49513Google Scholar
  8. 8.
    Collee, J.G.Duguid, J.P.Farser, A.G.Marmion, B.D. eds. 1989Practical Medical MicrobiologyChurchill LivingstoneNew YorkGoogle Scholar
  9. 9.
    Geary, W.J. 1971Coord. Chem. Rev.781CrossRefGoogle Scholar
  10. 10.
    Neena, S., Sunita, H., Jyoti, S., Vanita, P., Agarwala, B.V. 1992Synth. React. Inorg. Met.-Org. Chem.221283Google Scholar
  11. 11.
    Ferraro, J.R. 1971Low Frequency Vibrations of Inorganic and Coordination CompoundsPlenum PressNew YorkGoogle Scholar
  12. 12.
    Parihari, R.K., Patel, R.K., Patel, R.N. 2000J. Ind. Chem. Soc.77339Google Scholar
  13. 13.
    Thimmaiah, K.N., Lloyd, W.D., Chandrappa, G.T. 1985Inorg. Chim. Acta10681CrossRefGoogle Scholar
  14. 14.
    D. N. Sathyanarayana, Electronic Absorption Spectroscopy and Related Techniques. University Press (India) Limited (2001).Google Scholar
  15. 15.
    Gray, H.B., Ballhausen, C.J. 1963J. Am. Chem. Soc.85260CrossRefGoogle Scholar
  16. 16.
    Nawar, N., Khattab, M.A., Hosny, N.M. 1990Synth. React. Inorg. Met.-Org. Chem.291365Google Scholar
  17. 17.
    Todor, D., Carmay, L. 2000J. Am. Chem. Soc.12211146CrossRefGoogle Scholar
  18. 18.
    Singh, B., Yadev, B.P., Aggarwal, R.C. 1984Ind. J. Chem.23A441Google Scholar
  19. 19.
    Kivelson, D., Neiman, R. 1961J. Chem. Phys.35149CrossRefGoogle Scholar
  20. 20.
    Shetty, S.N., Murthy, A.S.R., Timbe, G.L. 1993Ind. J. Chem.32A318Google Scholar
  21. 21.
    Bard, A.J., Faulkner, L.R. 1980Electrochemical MethodsWileyNew YorkGoogle Scholar
  22. 22.
    Hentry, N.F.M., Lipson, H., Wooster, W.A. 1951Interpretation of X-ray Diffraction PhotographsMcMillanLondonGoogle Scholar
  23. 23.
    D’Eye, R.W.M., Wait, E. 1960X-ray Powder Photography in Inorganic ChemistryButterwothsLondonGoogle Scholar
  24. 24.
    Franklin, T.J., Snow, G.A. 1971Biochemistry of Antimicrobial Action2Chapman and HallLondonGoogle Scholar
  25. 25.
    W. Levingson, P. Mikeleus, J. Jackson and W. Kaska, in Inorganic and Nutritional Aspects of Cancer, G. N. Schranzer (ed.), Plenum Press, New York (1978).Google Scholar

Copyright information

© Springer 2006

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of KeralaTrivandrumIndia

Personalised recommendations