Lethal concentrations of mercury or lead do not affect coagulation kinetics in human plasma
- 40 Downloads
To the Editor,
Chronic or acute poisoning with mercury (Hg) or lead (Pb) containing compounds has resulted in multisystem dysfunction in adults and children, leading to significant short term or permanent morbidity, and death [1, 2]. Exposure to very small quantities of either of these elements is potentially toxic, with blood concentrations of Hg < 10 µg/l and Pb < 20–50 µg/l associated with little or no toxicity [3, 4]. Toxicity is variable at concentrations greater than these, but up to three orders of magnitude blood concentrations of both elements have been clinically encountered in sublethal and lethal circumstances following acute or chronic poisoning [5, 6]. Of interest, early canine  and rat  models of Hg poisoning demonstrated Hg-mediated increased circulating fibrinogen concentrations and hypercoagulability in whole blood with thrombelastography. Further, platelet activation was increased in the presence of Hg-containing compounds , and myocardial infarction risk...
This investigation was supported by the Department of Anesthesiology, College of Medicine, at the University of Arizona.
Compliance with ethical standards
Conflict of interest
The author declares that he has no conflict of interest.
This was an in vitro investigation and did not involve any living subjects.
- 10.Wennberg M, Strömberg U, Bergdahl IA, Jansson JH, Kauhanen J, Norberg M, Salonen JT, Skerfving S, Tuomainen TP, Vessby B, Virtanen JK (2012) Myocardial infarction in relation to mercury and fatty acids from fish: a risk-benefit analysis based on pooled Finnish and Swedish data in men. Am J Clin Nutr 96:706–713CrossRefGoogle Scholar