Association study of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with venous thromboembolism in a Korean population

  • Jung Oh Kim
  • Hyun Woo Kim
  • Hui Jeong An
  • Ok Joon Kim
  • Jisu Oh
  • So Young Chong
  • Won-Il Choi
  • Doyeun Oh
  • Nam Keun Kim


Despite much progress in microRNA (miRNA) research, information regarding the association between miRNAs and venous thromboembolism (VTE), especially in Asian patients, remains limited. This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. We observed no statistically significant differences in the genotype frequency of miRNA polymorphisms between 300 control individuals and 203 VTE patients. However, we observed a significant association between three allelic combinations of miRNA polymorphisms and VTE risk. Overall, our findings suggest that specific miRNA polymorphisms are associated with the risk of VTE in a Korean population.


Deep vein thrombosis MicroRNA Single nucleotide polymorphism Pulmonary embolism 



This study was partially supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, South Korea (HI16C1559 & HI18C19990200) and partially supported by National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2016R1D1A1B03930141 & NRF-2017R1D1A1B03029582).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All study protocols of participants were reviewed and approved by The Institutional Review Board of CHA Bundang Medical Center and followed the recommendations of the Declaration of Helsinki.

Informed consent

Written informed consent was obtained from all the participants.

Supplementary material

11239_2018_1778_MOESM1_ESM.doc (372 kb)
Supplementary material 1 (DOC 371 KB)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Jung Oh Kim
    • 1
  • Hyun Woo Kim
    • 1
  • Hui Jeong An
    • 1
  • Ok Joon Kim
    • 2
  • Jisu Oh
    • 3
  • So Young Chong
    • 3
  • Won-Il Choi
    • 4
  • Doyeun Oh
    • 3
  • Nam Keun Kim
    • 1
  1. 1.Department of Biomedical Science, College of Life ScienceCHA UniversitySeongnamSouth Korea
  2. 2.Department of Neurology, CHA Bundang Medical Center, School of MedicineCHA UniversitySeongnamSouth Korea
  3. 3.Department of Internal Medicine, CHA Bundang Medical CenterCHA UniversitySeongnamSouth Korea
  4. 4.Department of Internal Medicine, Keimyung University School of MedicineKeimyung University Dongsan Medical CenterDaeguSouth Korea

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