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Journal of Thrombosis and Thrombolysis

, Volume 46, Issue 1, pp 74–76 | Cite as

PFO closure for secondary stroke prevention: is the discussion closed?

  • Joseph J. ShatzelEmail author
  • Molly M. Daughety
  • Vinay Prasad
  • Thomas G. DeLoughery
Letter to the Editor

Abstract

Three previous reports of PFO closure for secondary stroke prevention failed to find any significant benefit. Recently however, three conflicting reports were published suggesting a benefit in select patients. Although we are enthusiastic for PFO closure in appropriate patients, caution is warranted in the extrapolation of this data and the application of this intervention to broader patient groups. Only small minorities of stroke patients are likely to benefit from PFO closure, the intervention has a notable complication rate, and it has not been compared against modern anticoagulation options. Clinicians should consider all of these points as discussions around PFO closure are likely to become more and more common going forward.

Keywords

PFO Stroke PFO closure Anticoagulation 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Joseph J. Shatzel
    • 1
    • 2
    Email author
  • Molly M. Daughety
    • 1
  • Vinay Prasad
    • 1
  • Thomas G. DeLoughery
    • 1
  1. 1.Department of Hematology, Knight Cancer InstituteOregon Health and Science UniversityPortlandUSA
  2. 2.Department of Hematology & OncologyOregon Health & Science UniversityPortlandUSA

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