In-vitro thrombogenicity assessment of flow diversion and aneurysm bridging devices
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Endoluminal devices such as metallic flow diversion (FD) and aneurysm bridging (AB) stents are used for treatment of intracranial aneurysms. Treatments are associated with thrombogenic events mandating the use of dual antiplatelet therapy in all cases. In the current in vitro study, we utilize a slow binding fluorogenic thrombin specific substrate to measure the thrombin generation potential of six devices: four FD devices (Pipeline™ Flex embolization device, Pipeline™ Flex embolization device with Shield Technology™, SILK+, FRED™) and two AB devices (Solitaire™ AB, LEO+). We show that the Pipeline™ Flex embolization device with Shield Technology™ has significantly lower peak thrombin and takes significantly longer time to achieve peak thrombin (time to peak) compared to the other three FD devices (p < 0.05), with statistically similar results to the less thrombogenic AB devices. We conclude that surface modification of endoluminal stents could be an effective method to mitigate thrombogenic complications.
KeywordsThrombin generation Flow diversion devices Aneurysm bridging devices
Compliance with ethical standards
This study was funded through a contract with Medtronic plc. Gaurav Girdhar, Junwei Li and John Wainwright all are employed by Medtronic plc. Wayne Chandler has full control of all primary data and agrees to allow the journal to review the data if requested.
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