Journal of Thrombosis and Thrombolysis

, Volume 39, Issue 3, pp 264–272 | Cite as

Anticoagulation therapy in 2015: where we are and where we are going

Article

Abstract

Oral anticoagulants are a mainstay for the prevention and treatment of venous and arterial thrombosis. In 2015, the non-vitamin K oral anticoagulants (NOACs) are already replacing warfarin for many indications. Ongoing studies are focused on development of antidotes and specific reversal agents for the NOACs, and assessing their utility for prevention of cardiovascular events in patients with heart failure, coronary or peripheral artery disease, or embolic stroke of unknown source. This paper (a) lists the current indications for the NOACs; (b) reviews the current impact of the NOACs in each of these indications; (c) outlines future opportunities for the NOACs, and (e) provides perspective on new anticoagulant strategies that may be safer than the NOACs.

Keywords

Anticoagulants Dabigatran Rivaroxaban Apixaban Antidotes Non-vitamin K oral anticoagulants 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Departments of Medicine and Biochemistry and Biomedical Sciences, The Thrombosis and Atherosclerosis Research InstituteMcMaster UniversityHamiltonCanada

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