Journal of Thrombosis and Thrombolysis

, Volume 35, Issue 3, pp 342–345

Bench to bedside: new developments in our understanding of the pathophysiology of thrombosis



There has been a resurgent interest in the molecular and cellular mechanisms of thrombogenesis in venous thromboembolism (VTE). Improved animal models of VTE, combined with high-resolution microscopy techniques, have helped to uncover novel roles for blood cells including platelets and innate immune cells, particularly neutrophils. These insights are likely to result in novel disease biomarkers and perhaps even adjunctive anti-thrombotic therapies.


Venous thrombosis Neutrophil extracellular traps Venous valve sinus Polyphosphates 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Departments of Medicine and Pathology and Laboratory MedicineUniversity of North CarolinaChapel HillUSA

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