Journal of Thrombosis and Thrombolysis

, Volume 33, Issue 1, pp 82–87 | Cite as

Venous thromboembolism in COPD hospitalized patients

  • Raquel Barba
  • Antonio Zapatero
  • Javier Marco
  • Juan E. Losa
  • Susana Plaza
  • Jose Manuel Casas
  • Jesús Canora


Patients with chronic obstructive pulmonary disease (COPD) are at increased risk for venous thromboembolism (VTE). We analyzed a large Spanish database to determine the incidence of VTE in these patients during hospitalization. A retrospective chart review of cohort of consecutive patients admitted with COPD as the primary reason for discharge in Spain between January 1st 2006 and December 31st 2007 was performed. For each patient, demographic data, risk factors for VTE and the diagnosis of VTE during hospitalization was recorded. We analyzed the clinical data of 313,233 adults with acute exacerbations of COPD admitted to the hospital at any public centre in Spain, in 2006 and 2007. We identify 3,562 new diagnosed VTE events among 270,840 COPD patients hospitalized more than two days (incidence 1.32%). Hospitalized-acquired VTE risk factors were male gender (odds ratio [OR] 1.77; CI95% 1.66–1.90), neoplasic disease (OR 2.93 CI95% 2.69–3.16, systemic arterial disease (OR 1.17 CI95% 1.10–1.36), decubitus ulcer (OR 1.19 CI95% 1.01–1.43), diabetes (OR 0.74 IC95% 0.69–0.81), and atrial fibrillation (OR 0.79 CI95% 0.72–0.87). VTE appears as a major threat to patients admitted for acute exacerbation of COPD, and pharmacologic prophylaxis should be considered in all high risk situations.


Venous thrombosis COPD Hospitalized patients 



The authors thank the Spanish Minister of Health for the permission to obtain of the data.

Conflicts of interest

None declared


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Raquel Barba
    • 1
  • Antonio Zapatero
    • 2
  • Javier Marco
    • 3
  • Juan E. Losa
    • 4
  • Susana Plaza
    • 5
  • Jose Manuel Casas
    • 1
  • Jesús Canora
    • 2
  1. 1.Servicio de Medicina InternaHospital Infanta CristinaParlaSpain
  2. 2.Servicio de Medicina InternaHospital Universitario de FuenlabradaFuenlabradaSpain
  3. 3.Servicio de Medicina InternaHospital Clínico de San CarlosMadridSpain
  4. 4.Servicio de Medicina InternaHospital Universitario Fundación AlcorcónAlcorcónSpain
  5. 5.Servicio de Medicina InternaHospital Severo OchoaLeganésSpain

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