Journal of Thrombosis and Thrombolysis

, Volume 31, Issue 4, pp 449–457 | Cite as

Acquired factor V inhibitors: a systematic review

  • Massimo Franchini
  • Giuseppe Lippi


The occurrence of an inhibitor against coagulation factor V (FV) is a rare but challenging condition, which may span from asymptomatic laboratory abnormalities to potentially life-threatening bleeding. The onset of FV inhibitors has been associated most frequently in the past with the patients’ exposure to topical bovine thrombin administered during surgery procedures. However, since this preparation is no longer used, in this systematic review we have only focused on non-bovine thrombin-related FV inhibitor cases.


FV inhibitors Autoantibodies Bleeding Therapy 


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di LaboratorioAzienda Ospedaliero-Universitaria di ParmaParmaItaly
  2. 2.U.O di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di LaboratorioAzienda Ospedaliero-Universitaria di ParmaParmaItaly

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