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Malignancy and hypercoagulability: a two-way association revisited


Increasing evidence is highlighting the relationship between malignancy and hypercoagulability as a bidirectional association. We herein share our experience with a patient in whom such an association may be entertained. The patient, who had a history of venous thromboembolism, presented to our care with manifestation of stroke. Extensive workup revealed that the patient carries prothrombotic mutations in the prothrombin and methylenetetrahydrofolate reductase genes. The patient, a non-smoker, was also diagnosed with non-small cell lung carcinoma. The possible association between the patient’s malignancy and prothrombotic state are further discussed.

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Correspondence to Ali T. Taher.

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Aoun, E.G., Musallam, K.M., Abou-Ghazal, M. et al. Malignancy and hypercoagulability: a two-way association revisited. J Thromb Thrombolysis 30, 340–341 (2010). https://doi.org/10.1007/s11239-010-0458-4

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  • Hypercoagulability
  • Lung cancer
  • Malignancy
  • Stroke
  • Thrombophilia
  • Venous thromboembolism