Advertisement

Journal of Thrombosis and Thrombolysis

, Volume 30, Issue 1, pp 112–113 | Cite as

Purtscher retinopathy as an initial presentation of thrombotic thrombocytopenic purpura

  • I. Tajunisah
  • D. K. Patel
  • V. Subrayan
Article

Purtscher retinopathy, first described secondary to severe head trauma, is characterized by retinal haemorrhages and cotton-wool spots in the posterior pole of the eye. It has been rarely associated with thrombotic thrombocytopenic purpura (TTP) and it is believed that abnormal platelet aggregations in TTP caused the microembolic occlusion of retinal precapillary arterioles. We present a case of Purtscher retinopathy as an initial presentation of TTP.

A 20-year-old woman was referred to ophthalmology unit for bilateral blurring of vision. She was admitted to the medical ward the previous day for evaluation of high grade fever, generalised petechiae, facial edema and pleural effusion of 1-week duration. Full blood count showed low haemoglobin of 86 g/l (normal 130–177 g/l), white cell count of 2.2 × 109 cells/l (normal 4.0–11.0 × 109 cells/l) with 29% eosinophilia and low platelet count of 145 × 109 cells/l (normal 150–400 × 109cells/l). Peripheral blood smear showed schistocytosis...

Keywords

Acute Pancreatitis Hemolytic Uremic Syndrome Thrombotic Thrombocytopenic Purpura Retinal Haemorrhage Severe Head Trauma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Percival SP (1970) Ocular findings in thrombotic thrombocytopenic purpura (Moschcowitzs Disease). Brit J Ophthal 54:73CrossRefPubMedGoogle Scholar
  2. 2.
    Hayreh SS, Zimmerman MB, Podhajsky BSN (1994) Incidence of various types of retinal vein occlusion and their recurrences and demographic characteristics. Am J Ophthal 117:429–441PubMedGoogle Scholar
  3. 3.
    Gass JDM (1987) Stereoscopic atlas of macular diseases: diagnosis and treatment. Mosby-Year Book Inc, St Louis, MO, pp 346–348, 558–559Google Scholar
  4. 4.
    Power M, Regillo CD, Curtis PH (1997) Thrombotic thrombocytopenic purpura associated with purtscher retinopathy. Arch Ophthalmol 115:128–129PubMedGoogle Scholar
  5. 5.
    Tsai H-M, Lian EC-Y (1998) Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura. N Eng J Med 339:1585–1594CrossRefGoogle Scholar
  6. 6.
    Scheurer G, Praetorius G, Damerau B et al (1992) Vascularocclusion of the retina: an experimental model. I. Leukocyte aggregates. Graefes Arch Clin Exp Ophthalmol 230:275–280CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Ophthalmology, Faculty of MedicineUniversity of MalayaKuala LumpurMalaysia

Personalised recommendations