Journal of Thrombosis and Thrombolysis

, Volume 29, Issue 3, pp 354–357

Thrombotic storm in Kimura disease



We report herein a patient with Kimura disease who experienced life threatening visceral venous thromboses and a clinical course fitting the description of “thrombotic storm”. Kimura disease is an indolent chronic inflammatory disease common in Asians and characterized by angiolymphoid proliferation with ample eosinophil infiltration, peripheral blood eosinophilia and elevated serum immunoglobulin E levels. The clinical course of the disease is thought to be benign. Our patient experienced a major thrombotic event with a thorough evaluation revealing no evidence of inherited thrombophilia or acquired conditions associated with visceral venous thromboembolism. Despite persisting eosinophilia and other manifestations of Kimura disease there have been no recurrent thrombotic events with continuous warfarin therapy over a 4-year period. This case highlights the occurrence of hypercoagulability in association with this unusual eosinophilic disorder.


Kimura disease Thrombosis Hypercoagulability Hypereosinophilia 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Hong Liu
    • 1
  • Samer Z. Al-Quran
    • 2
  • Richard Lottenberg
    • 1
  1. 1.Department of Medicine, Division of Hematology/OncologyUniversity of Florida College of MedicineGainesvilleUSA
  2. 2.Department of PathologyUniversity of Florida College of MedicineGainesvilleUSA

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