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Incidence and cost burden of post-thrombotic syndrome

  • Aneel A. Ashrani
  • John A. Heit
Article

Abstract

Post-thrombotic syndrome (PTS) is a long-term complication of deep-vein thrombosis (DVT), manifesting as swelling, pain, edema, venous ectasia, and skin induration of the affected limb. PTS has been estimated to affect 23–60% of individuals with DVT, frequently occurring within 2 years of the DVT episode. Symptomatic DVT, post-operative asymptomatic DVT, and recurrent DVT are all risk factors for the development of PTS. Treatment of PTS is often ineffective and treatment-related costs represent a healthcare burden. Therefore, prevention of DVT is essential to reduce PTS, and thus improve outcomes and reduce overall healthcare costs. Although recommended by guidelines, appropriate DVT prophylaxis remains considerably underused. This review evaluates the incidence, risk factors, and economic impact of PTS. Increasing the awareness of PTS, and the methods to prevent this complication may help reduce its incidence, improve long-term outcomes in patients, and decrease resulting costs associated with treatment.

Keywords

Anticoagulant therapy Deep-vein thrombosis Post-thrombotic syndrome Venous leg ulcers 

Notes

Acknowledgments

The authors received editorial support in the preparation of this manuscript, funded by sanofi-aventis, NJ, USA. The authors are fully responsible for content and editorial decisions for this manuscript.

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Division of Hematology, Department of Internal Medicine, Stabile 6-60Mayo ClinicRochesterUSA
  2. 2.Divisions of Cardiovascular Medicine and Hematology Research, Department of Internal MedicineMayo ClinicRochesterUSA

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