Journal of Thrombosis and Thrombolysis

, Volume 26, Issue 1, pp 31–34 | Cite as

Livedoid vasculopathy associated with combined prothrombin G20210A and factor V (Leiden) heterozygosity and MTHFR C677T homozygosity

  • Noha A. Irani-Hakime
  • Farid Stephan
  • Raghid Kreidy
  • Isabelle Jureidini
  • Wassim Y. AlmawiEmail author


Livedoid vasculopathy (LV) is an occlusive thrombotic disease of lower extremities. A 34-year-old woman presented with 4-year history of recurrent necrotic and painful lesions with violaceous and purpuric border on both legs. Initial treatment with hydroxychloroquine, dapsone and prednisone were unsuccessful. Skin biopsy showed inflammatory infiltrate with epidermal necrosis. Prothrombin G20210A and factor V-Leiden heterozygosity, and MTHFR C677T homozygosity with hyperhomocysteinemia were confirmed. LV diagnosis was made; acetylsalicylic acid, folic acid, vitamin B12, and prednisone treatement resulted in complete healing. This is the first report on coexistence of prothrombin G20210A, factor V-Leiden, and homozygous MTHFR C677T with hyperhomocysteinemia in LV.


Livedoid vasculopathy Factor V-Leiden Prothrombin G20210A MTHFR C677T 


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Noha A. Irani-Hakime
    • 1
  • Farid Stephan
    • 2
  • Raghid Kreidy
    • 3
  • Isabelle Jureidini
    • 1
  • Wassim Y. Almawi
    • 4
    Email author
  1. 1.Department of Laboratory MedicineSt. Georges University HospitalBeirutLebanon
  2. 2.Department of DermatologySt. Georges University HospitalBeirutLebanon
  3. 3.Department of Vascular SurgerySt. Georges University HospitalBeirutLebanon
  4. 4.Department of Medical BiochemistryArabian Gulf UniversityManamaBahrain

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