Journal of Thrombosis and Thrombolysis

, Volume 26, Issue 3, pp 175–182

Bleeding after antithrombotic therapy in patients with acute ischemic heart disease

Is it the drugs or how we use them?
Article

DOI: 10.1007/s11239-007-0182-x

Cite this article as:
Cohen, M., Alexander, K.P. & Rao, S.V. J Thromb Thrombolysis (2008) 26: 175. doi:10.1007/s11239-007-0182-x

Abstract

Definitions of bleeding must be considered when evaluating results of clinical trials. Assessments of bleeding impact based on clinical criteria may be more relevant to patient outcomes than those based on simple laboratory measures like an isolated change in hemoglobin, that do not appear to affect patient care. The risk of excessive bleeding in patients who receive antiplatelet and antithrombotic therapy is related to a combination of patient characteristics (older age, female sex, impaired renal function), and delivery factors (excessive dosing, stacking of anticoagulants). Investigators should justify components of bleeding endpoints as being clinically meaningful, sufficiently frequent in the study population, and affected by the intervention.

Keywords

Bleeding Acute coronary syndrome Hemorrhage Percutaneous coronary intervention 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Marc Cohen
    • 1
  • Karen P. Alexander
    • 2
  • Sunil V. Rao
    • 2
  1. 1.The Division of CardiologyNewark Beth Israel Medical CenterNewarkUSA
  2. 2.The Division of CardiologyDuke University Medical CenterDurhamUSA

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