Polymorphism in the methylenetetrahydrofolate reductase (C677T) gene and homocysteine levels: a comparison in Brazilian patients with coronary arterial disease, ischemic stroke and peripheral arterial obstructive disease

  • Adriano Sabino
  • Ana Paula Fernandes
  • Luciana Moreira Lima
  • Daniel Dias Ribeiro
  • Marinez Oliveira Sousa
  • Maria Elizabeth Rennó de Castro Santos
  • Ana Paula Lucas Mota
  • Luci Maria Sant’Ana  Dusse
  • Maria das Graças Carvalho
Article

DOI: 10.1007/s11239-007-0172-z

Cite this article as:
Sabino, A., Fernandes, A.P., Lima, L.M. et al. J Thromb Thrombolysis (2009) 27: 82. doi:10.1007/s11239-007-0172-z

Abstract

This study aimed to compare plasma levels of total homocysteine (tHcy) in different arterial events as well as to investigate an association between homocysteine levels and C677T polymorphism in Brazilian patients. A total of 145 subjects were enrolled in this study including 43 patients with coronary arterial disease (CAD), 21 with ischemic stroke (IS), 44 with peripheral arterial obstructive disease (PAOD) and 37 control subjects. A preliminary analysis showed significant difference for tHcy plasma levels between patients with CAD (P = 0.003) or PAOD (P = 0.03) compared to controls. However, after adjustment for sex, age, total cholesterol, LDL, diabetes, tabagism or C677T polymorphism, no significant differences were detected in tHcy levels among patients groups and controls. No significant correlation was demonstrated for C677T polymorphism and homocysteine levels. These results indicate that increased Hcy levels may not be considered an independent risk factor for atherothrombotic diseases in Brazilian patients.

Keywords

Homocysteine MTHFR Ischemic stroke Coronary arterial disease and peripheral arterial obstructive disease 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Adriano Sabino
    • 1
  • Ana Paula Fernandes
    • 1
  • Luciana Moreira Lima
    • 1
  • Daniel Dias Ribeiro
    • 2
  • Marinez Oliveira Sousa
    • 1
  • Maria Elizabeth Rennó de Castro Santos
    • 3
  • Ana Paula Lucas Mota
    • 1
  • Luci Maria Sant’Ana  Dusse
    • 1
  • Maria das Graças Carvalho
    • 1
  1. 1.Faculty of PharmacyFederal University of Minas GeraisBelo HorizonteBrazil
  2. 2.Faculty of MedicineFederal University of Minas GeraisBelo HorizonteBrazil
  3. 3.Santa Casa de Misericórdia de Belo HorizonteBelo HorizonteBrazil

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