Challenges in the treatment of patients with essential thrombocythemia and acute coronary syndrome

  • Christina Doesch
  • Björn Krämer
  • Tobias Geisler
  • Andreas E. May
  • Stefan-Martin Kroeber
  • Reinhard Kandolf
  • Meinrad Gawaz


Essential thrombocythemia (ET) is an acquired clonal hematological stem-cell disorder that is characterized by a persistent increase in platelet count over 600,000/μl and elevated megakaryocyte levels in the bone marrow. Patients with ET are on the one hand at risk of thrombosis and on the other hand of hemorrhagic events especially in patients with very high platelet accounts. We report two illustrative cases with ET and acute coronary syndrome from our recent clinical experience illustrating the challenges in the antithrombotic treatment of these patients.


Essential thrombocythemia Thrombosis Acute coronary syndrome Cytoreductive treatment Antiplatelet therapy 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Christina Doesch
    • 1
  • Björn Krämer
    • 1
  • Tobias Geisler
    • 1
  • Andreas E. May
    • 1
  • Stefan-Martin Kroeber
    • 2
  • Reinhard Kandolf
    • 3
  • Meinrad Gawaz
    • 1
  1. 1.Department of Cardiology and Cardiovascular DiseaseTuebingenGermany
  2. 2.Institute of Pathology KoblenzKoblenzGermany
  3. 3.Institute of Molecular PathologyTuebingenGermany

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