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The lack of endothelization after drug-eluting stent implantation as a cause of fatal late stent thrombosis

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Abstract

The authors present a fatal case of late thrombosis of paclitaxel-eluting stent implanted in the left main stem occurring 6 months after the procedure and 3 weeks after the cessation of clopidogrel. An autopsy has shown the lack of endothelization of deployed stent.

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References

  1. 1.

    Sousa JE, Costa MA, Abizaid AC et al (2001) Sustained supression of neointimal proliferation bz sirolimus-eluting stents. One-year angiographic and intravascular ultrasound follow-up. Circulation 104:2007–2011

  2. 2.

    Morice MC, Serruys PW, Sousa JE et al (2002) A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. N Engl J Med 346:1773–1780

  3. 3.

    Moses JW, Leon MB, Popma JJ et al, SIRIUS Investigators (2003) Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med 349:1315–1323

  4. 4.

    Schofer J, Schluter M, Gershlick AH et al, E-SIRIUS Investigators (2003) Sirolimus-eluting stents for treatment of patients with long atherosclerotic lesions in small coronary arteries: double-blind, randomized controlled trial (E-SIRIUS). Lancet 362:1093–1099

  5. 5.

    Hong MK, Mintz GS, Lee CW et al, Asian Paclitaxel-Eluting Stent Clinical Trial Investigators (2003) Paclitaxel coating reduces in-stent intimal hyperplasia in human coronary arteries: a serial volumetric intravascular ultrasound analysis from the Asian Paclitaxel-Eluting Stent Clinical Trial (ASPECT). Circulation 107:517–520

  6. 6.

    Grube E, Silber S, Hauptmann KE et al (2003) TAXUS I: six- and twelve-month results from a randomized, double-blind trial on a slow-release paclitaxel-eluting stent for de novo coronary lesions. Circulation 107:38–42

  7. 7.

    Stone GW, Ellis SG, Cox DA et al, TAXUS-IV Investigators (2004) A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease. N Engl J Med 350:221–231

  8. 8.

    Pfisterer ME, Kaiser CA, Bader F et al (2006) Late clinical events related to late stent thrombosis after stopping clopidogrel: prospective randomized comparison between dru-eluting versus bare-metal stenting. Program and abstracts from the American College of Cardiology 55th Annual Scientific Session, March 11–14, 2006, Atlanta, Georgia. Abstract 422–11

  9. 9.

    Iakovou I, Schnidt T, Bonizzoni E et al (2005) Incidence, predictors and outcome of thrombosis after successful implantation of drug-eluting stents. JAMA 293:2126–2130

  10. 10.

    Kuchulakanti PK, Chu WW, Torguson R et al (2006) Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolimus- and paclitaxel-eluting stents. Circulation 113:1108–1113

  11. 11.

    Takano M, Ohba T, Inami S et al (2006) Angioscopic differences in neointimal overage and in persistence of thrombus between sirolimus-eluting stents and bare metal stents after a 6-month implantation. EHJ 27:2189–2195

  12. 12.

    Virmani R, Guagliumi G, Farb A et al (2004) Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious? Circulation 109:701–705

  13. 13.

    Ong A, McFadden E, Regar E et al (2005) Late angiographic stent thrombosis (LAST) events with drug-eluting stents. J Am Coll Cardiol 45:2088–2092

  14. 14.

    Urban P, Gershlick A, Guagliumi G et al (2006) E-Cypher investigators. Safety of coronary sirolimus-eluting stents in daily clinical practice: one-year follow-up of the e-Cypher registry. Circulation 21:1434–1441

  15. 15.

    Moreno R, Fernandez C, Hernandez R et al (2005) Drug-eluting stent thrombosis: results from a pooled analysis including 10 randomized studies. J Am Coll Cardiol 45:954–959

  16. 16.

    Joner M, Finn AV, Farb A et al (2006) Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol 48:193–202

  17. 17.

    Laarman GJ, Suttorp MJ, Dirksen MT et al (2006) Paclitaxel-eluting versus uncoated stents in primary percutaneous coronary intervention. N Engl J Med 355:1105–1113

  18. 18.

    Spaulding C, Henry P, Teiger E et al (2006) Sirolimus-eluting versus uncoated stents in acute myocardial infarction. N Engl J Med 355:1093–1104

  19. 19.

    Valgimigli M, van Mieghem CAG, Ong ATL et al (2005) Short- and long-term clinical outcome after drug-eluting stent implantation for the percutaneous treatment of left main coronary artery disease. Insights from the rapamycin-eluting and taxus stent evaluated at Rotterdam cardiology hospital registries (RESEARCH and T-SEARCH). Circulation 111:1383–1389

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Author information

Correspondence to Jozef Jakabčin or Pavel Červinka.

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Jakabčin, J., Bystroň, M., Špaček, R. et al. The lack of endothelization after drug-eluting stent implantation as a cause of fatal late stent thrombosis. J Thromb Thrombolysis 26, 154–158 (2008). https://doi.org/10.1007/s11239-007-0080-2

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Keywords

  • Late stent thrombosis
  • Paclitaxel-eluting stent
  • Coronary intervention
  • Drug-eluting stent
  • Acute myocardial infarction
  • Percutaneous coronary interventions of left main stem
  • Dual antiplatelet treatment