Journal of Thrombosis and Thrombolysis

, Volume 26, Issue 1, pp 71–73 | Cite as

A case of disseminated intravascular coagulation caused by Brucella melitensis

  • Tuba TuruncEmail author
  • Yusuf Ziya Demiroglu
  • Ebru Kizilkilic
  • Hikmet Aliskan
  • Can Boga
  • Hande Arslan



Although the haematological abnormalities were common accompaniments of brucellosis, overt disseminated intravascular coagulopathy was reported only in a case at the literature. We report here a case of Brucella melitensis sepsis which showed an acute onset with clinical and hematological findings disseminated intravascular coagulopathy


The patient had a physical examination, coagulation screening tests, tests of thrombin generation and fibrinolysis, bone marrow aspirate, serum Brucella agglutination test and blood culture. A case of Brucella infection presenting at the onset as a disseminated intravascular coagulation with gingival bleeding and echimotic lesions on abdomen is reported. A hemogram showed severe thrombocytopenia, anemia, and leukopenia. Anisocytozis, poikilocytozis, shift to the left of the granulocytic series, fragmented red blood cells, toksic granulation, were present in the peripheral smear. Bone marrow aspirate revealed a hypercellular marrow without granulomata or malignant precursors. Prothrombin time: 20 s, activated partial thromboplastin time:53.9 s were found longer than normal. D-dimer: 1056 μg/l (50–228 μg/l) was found. Fibrinogen was too low to detected in serum. Patient had Brucella melitensis isolated from blood cultures.


After appropriate antimicrobial therapy, the clinical and hematological status of the patient improved, and 4 days later with disappearance of all hematological abnormalities. Conclusison: Diagnosis of brucellosis may be delayed, particularly if uncommon features such as pancytopenia and disseminated intravascular coagulopathy are present. Hence, brucellosis must be considered in the differential diagnosis of all those conditions leading to pancytopenia and disseminated intravascular coagulopathy in areas endemic for brucellosis.


Disseminated intravascular coagulopathy Brucellosis 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Tuba Turunc
    • 1
    • 2
    Email author
  • Yusuf Ziya Demiroglu
    • 1
  • Ebru Kizilkilic
    • 3
  • Hikmet Aliskan
    • 4
  • Can Boga
    • 3
  • Hande Arslan
    • 1
  1. 1.Department of Infectious Diseases and Clinical Microbiology, Faculty of MedicineBaşkent UniversityAnkaraTurkey
  2. 2.Department of Infectious Diseases and Clinical MicrobiologyBaşkent University Faculty of Medicine Adana Researching and Practice CenterAdanaTurkey
  3. 3.Department of Hematology, Faculty of MedicineBaşkent UniversityAnkaraTurkey
  4. 4.Department of Clinical Microbiology and Microbiology, Faculty of MedicineBaşkent UnivesityAnkaraTurkey

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