Journal of Thrombosis and Thrombolysis

, Volume 25, Issue 2, pp 219–223 | Cite as

Microbubble potentiated transcranial duplex ultrasound enhances IV thrombolysis in acute stroke

  • Fabienne Perren
  • Jaouad Loulidi
  • Davide Poglia
  • Theodor Landis
  • Roman Sztajzel



We studied whether 2 MHz transcranial color-coded duplex ultrasound (TCCD), combined with a second generation ECA, accelerate IV rtPA-thrombolysis in the acute phase of MCA stroke more than TCCD monitoring alone.


Non-randomized acute MCA stroke patients undergoing IV rtPA-thrombolysis and 2 MHZ-TCCD monitoring over 60 min, with (N = 11) or without (N = 15) additional continuous ECA (5 ml, SonoVue®) perfusion, were compared. Recanalization of the MCA was measured pre- and post-thrombolysis with the thrombolysis in brain ischemia (TIBI) grading system, clinical outcome was assessed at admission and 24 h after treatment using the NIH stroke scale (NIHSS).


Patients who received ECA improved their NIHSS significantly more than those who were only TCCD monitored (Mann–Whitney U = 48.0; P = 0.050), and their flow signal improved more (Mann–Whitney U = 40.0; P < 0.03).


The results of this pilot study show that in IV-thrombolysis the use of ECA in addition to TCCD monitoring lead to a greater immediate clinical improvement and to a better flow signal.


Stroke Thrombolysis Transcranial ultrasound Microbubbles 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Fabienne Perren
    • 1
  • Jaouad Loulidi
    • 1
  • Davide Poglia
    • 1
  • Theodor Landis
    • 1
  • Roman Sztajzel
    • 1
  1. 1.Department of Neurology, Neurosonology UnitHUG, University Hospital and Medical School of GenevaGeneva 14Switzerland

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