Reducing mind to molecular pathways: explicating the reductionism implicit in current cellular and molecular neuroscience
- 507 Downloads
- 47 Citations
Abstract
As opposed to the dismissive attitude toward reductionism that is popular in current philosophy of mind, a “ruthless reductionism” is alive and thriving in “molecular and cellular cognition”—a field of research within cellular and molecular neuroscience, the current mainstream of the discipline. Basic experimental practices and emerging results from this field imply that two common assertions by philosophers and cognitive scientists are false: (1) that we do not know much about how the brain works, and (2) that lower-level neuroscience cannot explain cognition and complex behavior directly. These experimental practices involve intervening directly with molecular components of sub-cellular and gene expression pathways in neurons and then measuring specific behaviors. These behaviors are tracked using tests that are widely accepted by experimental psychologists to study the psychological phenomenon at issue (e.g., memory, attention, and perception). Here I illustrate these practices and their importance for explanation and reduction in current mainstream neuroscience by describing recent work on social recognition memory in mammals.
Keywords
Reduction Long-term potentiation (LTP) Social recognition memory consolidation Molecular mechanismPreview
Unable to display preview. Download preview PDF.
References
- Abel T., Nguyen P., Barad M., Deuel T., Kandel E.R., Bourtchouladze R. (1997). Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell. 88, 615–626CrossRefGoogle Scholar
- Bailey C.H., Bartsch D., Kandel E.R. (1996). Toward a molecular definition of long-term memory storage. Proceedings of the National Academy of Sciences (USA). 93, 13445–13452CrossRefGoogle Scholar
- Balzer W., Moulines C.U., Sneed J.D. (1987). An Architectonic for science. Dordrecht, ReidelGoogle Scholar
- Bechtel W. (2001). Decomposing and localizing vision: an exemplar for cognitive neuroscience. In: Bechtel W., Mandik P., Mundale J., Stufflebeam R.S.(eds) Philosophy and the neurosciences: a reader. Oxford, Basil BlackwellGoogle Scholar
- Bechtel W., Mandik P., Mundale J., Stufflebeam R.S. (2001). Philosophy and the neurosciences: a reader. Oxford, Basil BlackwellGoogle Scholar
- Bechtel W., Mundale J. (1999). Multiple realizability revisited: linking cognitive and neural states. Philosophy of Science. 66, 175–207CrossRefGoogle Scholar
- Bechtel W., Richardson R.C. (1993). Discovering complexity. Princeton, NJ: Princeton University PressGoogle Scholar
- Bickle J. (1998). Psychoneural reduction: The new wave. Cambridge, MA: MIT PressGoogle Scholar
- Bickle J. (2003). Philosophy and neuroscience: A ruthlessly reductive account. Drodrecht, Kluwer Academic PublishingGoogle Scholar
- Bourtchouladze R., Frenguelli B., Blendy J., Cioffi D., Schutz G., Silva A. (1994). Deficient long-term memory in micewith a targeted mutation of the cAMP-responsive element binding protein. Cell. 79, 59–68CrossRefGoogle Scholar
- Chain D., Casadio A., Schacher S., Hegde A., Valbrun M., Yamamoto N., Goldberg A., Bartsch D., Kandel E. R., Schwartz J. (1999). Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia. Neuron. 22, 147–156CrossRefGoogle Scholar
- Churchland P.S. (1986). Neurophilosophy. Cambridge, MA: MIT PressGoogle Scholar
- Churchland P.S., Sejnowski T.J. (1992). The computational brain. Cambridge, MA: MIT PressGoogle Scholar
- Craver C.F. (2002). Interlevel experiments and multilevel mechanisms in the neuroscience of memory. Philosophy of Science Supplemental. 69, S83–97Google Scholar
- Craver C.F. (2003). The making of a memory mechanism. Journal of the History of Biology. 36, 153–195CrossRefGoogle Scholar
- Craver C.F., Darden L. (2001). Discovering mechanisms in neurobiology: the case of spatial memory”. In: Machamer P.,Grush R., McLaughlin P.(eds). Theory and method in neuroscience. Pittsburgh, PA: University of Pittsburgh Press, 112–135Google Scholar
- Ferguson J.N., Young L.J., Insell T.R. (2002). The neuroendocrine basis of social recognition. Frontiers in Neuroendocrinology 23, 200–224CrossRefGoogle Scholar
- Feyerabend P.K. (1962). Explanation, reduction and empiricism. Minnesota Studies in the Philosophy of Science. 3, 28–97Google Scholar
- Frey U., Huang Y.-Y., Kandel E.R. (1993). Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science. 260: 1661–1664CrossRefGoogle Scholar
- Gallistel C.R. (1995). Is LTP a plausible basis for memory?. In: McGaugh J.L., Weinberger N.M., Lynch G.(eds). Brain and Memory: Modulation and mediation of neuroplasticity. New York, Oxford University Press, 328–337Google Scholar
- Hayashi Y., Shi S.-H., Esteban J.A., Piccini A., Poncer J.-C., Malinow R. (2000). Driving AMPA receptors into synapses by LTP and CaMKII: Requirements for GluR1 and PDZ domain interaction. Science. 287, 2262–2267CrossRefGoogle Scholar
- Huang Y. -Y., Li X.-C., Kandel E.R. (1994). cAMP contributes to mossy-fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase. Cell. 79, 69–79CrossRefGoogle Scholar
- Hummler E., Cole T., Blendy J., Ganss R., Aguzzi A., Schmid W., Beerman F., Schutz G. (1994). Targeted mutation of the CREB gene: Compensation with in the CREB/ATF family of transcription factors. Proceedings of the National Academy of Sciences USA. 91, 5647–5651CrossRefGoogle Scholar
- Jiang Y., Lee A., Chen J., Ruta V., Cadene M., Chalt B., MacKinnon R. (2003a). X-ray structure of a voltage-dependent K+ channel. Nature, 423, 33–41CrossRefGoogle Scholar
- Jiang Y., Ruta V., Chen J., Lee A., Mackinnon R. (2003b). The principle of gating charge movement in a voltage-dependent K+ channel. Nature, 423, 42–48CrossRefGoogle Scholar
- Kandel E.R., Schwartz J.R., Jessell T. (2000). Principles of neural science (4th ed). New York, McGraw-HillGoogle Scholar
- Kemeny J.G., Oppenheim P. (1956). On reduction. Philosophical Studies. 7, 6–19CrossRefGoogle Scholar
- Kim J. (1993). Supervenience and mind. Cambridge, Cambridge University PressGoogle Scholar
- Kogan J.H., Frankland P.W., Blendy J.A., Coblentz J., Marowitz Z., Schutz G., Silva A.J. (1997). Spaced training induces normal long-term memory in CREB mutant mice. Current Biology. 7, 1–11CrossRefGoogle Scholar
- Kogan J.H., Frankland P.W., Silva A.J. (2000). Long-term memory underlying hippocampus-dependent social recognition in mice. Hippocampus. 10, 47–56CrossRefGoogle Scholar
- Larson J., Wong D., Lynch G. (1986). Patterned stimulation at the theta frequency is optimal for induction of hippocampal long-term potentiation. Brain Research. 368, 347–350CrossRefGoogle Scholar
- LePore E., Loewer B. (1989). More on making mind matter. Philosophical Topics. 17, 175–191Google Scholar
- Lodish H., Berk A., Zipursky S., Baltimore D., Darnell J. (2000). Molecular Cell Biology (4th ed). New York, W.H. FreemanGoogle Scholar
- Lynch G. (1986). Synapses, Circuits, and the Beginnings of Memory. Cambridge, MA: MIT PressGoogle Scholar
- Machamer P., Darden L., Craver C.F. (2000). Thinking about mechanisms. Philosophy of Science. 67, 1–25CrossRefGoogle Scholar
- Macrides F., Eichenbaum H.B., Forbes W.B. (1982). Temporal relationship between sniffing and the limbic θ rhythm during odor discrimination reversal learning. Journal of Neuroscience. 2, 1705–1717Google Scholar
- Nagel E. (1961). The structure of science. New York, Harcourt, Brace, and WorldGoogle Scholar
- Salzman C.D., Murasagi C.M., Britten K.H., Newsome W.T. (1992). Microstimulation in visual area MT: Effects on direction discrimination performance. Journal of Neuroscience. 12, 2331–2355Google Scholar
- Schaffner K. (1967). Approaches to reduction. Philosophy of Science. 34, 137–147Google Scholar
- Schaffner K. (1993). Discovery and explanation in biology and medicine. Chicago, University of Chicago PressGoogle Scholar
- Shors T.J., Matzel L.D. (1997). Long-term potentiation: What’s learning got to do with it?. Behavioral and Brain Sciences. 20, 597–655Google Scholar
- Squire L.R. (1987). Memory and brain. Oxford, Oxford University PressGoogle Scholar
- Staubli U., Lynch G. (1987). Stable hippocampal long-term potentiation elicited by “theta” pattern stimulation. Brain Research. 435, 227–234CrossRefGoogle Scholar
- Suppes P. (1956). Introduction to logic. Princeton, NJ: van NostrandGoogle Scholar
- Taubenfeld S., Wiig K., Monti B., Dolan B., Pollonini G., Alberini C.C. (2001). Fornix-dependent induction of hippocampal CCAAT enhancer-binding protein β and δ co-localizes with phosphorylated cAMP response element-binding protein and accompanies long-term memory consolidation. Journal of Neuroscience. 21, 84–91Google Scholar
- Thor D.H., Holloway W.R. (1982). Social memory of the male laboratory rat. Journal of Comparative and Physiological Psychology. 96, 1000–1006CrossRefGoogle Scholar
- Vanderwolf C.H. (1969). Hippocampal electrical activity and voluntary movement in the rat. Electroencephalography and Clinical Neurophysiology. 26, 407–418CrossRefGoogle Scholar
- Wimsatt W.C. (1986). “Forms of aggregativity”. In: Donagan A., Perovich A.N., Wedin M.V.(eds). Human nature and natural knowledge. Dordrecht, Reidel, 259–291Google Scholar