Structural Chemistry

, Volume 30, Issue 1, pp 247–261 | Cite as

Thermochemistry of drugs: experimental and theoretical study of analgesics

  • Ruslan N. NagrimanovEmail author
  • Marat A. Ziganshin
  • Boris N. Solomonov
  • Sergey P. VerevkinEmail author
Original Research


Acetanilides are broadly used in the pharmaceutical industry. Thermochemical data on vapor pressures, solid-gas, liquid-gas, and solid-liquid phase transitions, as well as on enthalpies of formation of substituted acetanilides have been collected and evaluated with help of additional experimental measurements. Absolute vapor pressures of meta- and para-substituted acetanilides were studied by using transpiration method. Significant disagreement of available literature data on isomeric hydroxyacetanilides was detected and resolved. A quick estimation scheme of vaporization enthalpies of substituted acetanilides at 298.15 K was developed based on “structure-property” relationships. Quantum-chemical methods were applied for calculation of theoretical gas-phase enthalpies of formation of substituted acetanilides. Theoretical values together with results from “structure-property” analysis allowed for validation of the experimental crystalline state enthalpies of formation and prediction of these values based on quantum-chemical calculations.


Acetanilide derivatives Vapor pressures, enthalpy of sublimation Enthalpy of vaporization, enthalpy of fusion 



We gratefully acknowledge the contribution of Dr. Vladimir N. Emel’yanenko for quantum-chemical calculations.

Funding information

This work has been partly supported by the Russian Government Program of Competitive Growth of Kazan Federal University. R.N gratefully acknowledges the financial support by the research grant of Kazan Federal University and the financial support by the Russian Ministry of Education and Science No. 4.5289.2017/9.10. B.S. and gratefully acknowledges the financial support by the Russian Ministry of Education and Science No.4.5618.2017/6.7. This work has been partly supported by the German Science Foundation (DFG) in the frame of the priority program SPP 1807 “Control of London Dispersion Interactions in Molecular Chemistry”, as well as of the priority program SPP 1708 “Material Synthesis Near Room Temperature”.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

11224_2018_1188_MOESM1_ESM.docx (246 kb)
ESM 1 (DOCX 246 kb)


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Physical ChemistryKazan Federal UniversityKazanRussia
  2. 2.Chemical DepartmentSamara State Technical UniversitySamaraRussia
  3. 3.Department of Physical ChemistryUniversity of RostockRostockGermany

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