, Volume 71, Issue 1, pp 87–99 | Cite as

Research cooperation within the bio-pharmaceutical industry: Network analyses of co-publications within and between firms

  • Clara Calero
  • Thed N. van Leeuwen
  • Robert J. W. Tijssen
Open Access


Bio-pharmaceutical R&D is increasingly an international affair. Research articles published in the peer-reviewed international scientific and technical journals represent quantifiable research outputs of bio-pharmaceutical firms. Large-scale systemic measurements of worldwide trends and sectoral patterns within bio-pharmaceutical science can be gauged from these articles, where coauthored research papers are assumed to reflect research cooperation and associated knowledge flows and exchanges. We focus our attention on the largest science-based multinational enterprises (MNEs), those that produce relatively large quantities of research articles. The study deals with the worldwide output of research articles that are co-produced by corporate researchers during the years 1996–2001.

We employ these publications to examine structural factors characterizing research cooperation networks within industry at the level of major geographical regions (North America, Europe, Pacific-Asia), with a breakdown by within-MNE and between-MNE network linkages. The descriptive statistics on publication output and results of network analyses of co-publication linkages not only indicate regional differences, with a central role for US companies in biopharmaceutical research, but also a variety of firm-specific research cooperation networks which enabled us to develop a tentative typology of MNEs in terms of their intra- and interorganizational patterns of research cooperation linkages.


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Copyright information

© Akadémiai Kiadó 2007

Authors and Affiliations

  • Clara Calero
    • 1
  • Thed N. van Leeuwen
    • 1
  • Robert J. W. Tijssen
    • 1
  1. 1.Center for Science and Technology Studies (CWTS)Leiden UniversityRB LeidenThe Netherlands

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