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Synthesis of 5-phosphoryl-substituted 1,3,4(3H)-thiadiazolones

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Abstract

Reactions of various phosphorylthioformic acid morpholides with hydrazine afford phosphorylthioformhydrazides. The latter react under mild conditions with N, N′-carbonyldiimidazole to form novel 5-phosphoryl-1,3,4(3H)-thiadiazol-2-ones.

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Author information

Correspondence to Y. A. Volkova.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2105–2107, November, 2019.

This work was financially supported by the Russian Science Foundation (project No. 18-73-00321).

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Kozlov, M.A., Volkova, Y.A. & Zavarzin, I.V. Synthesis of 5-phosphoryl-substituted 1,3,4(3H)-thiadiazolones. Russ Chem Bull 68, 2105–2107 (2019). https://doi.org/10.1007/s11172-019-2673-2

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Key words

  • 5-phosphoryl-1,3,4(3H)-thiadiazol-2-ones
  • thiohydrazides
  • thiomorpholides
  • heterocyclization