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Antibacterial activity of [1Fe-2S]- and [2Fe-2S]-nitrosyl complexes as nitric oxide donors

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Abstract

The biological activity of a series of sulfur-nitrosyl iron complexes (NICs) depends on the structure of the ligands and the position of the functional groups in the aromatic ring of the ligand. Differences in susceptibility of the gram-positive and gram-negative bacteria to the NICs was found. The series of the studied NICs suppresses the formation of biofilms of Micrococcus luteus bacteria. The obtained results demonstrate that the studied complexes can serve as the basis for the preparation of antibacterial agents.

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Authors and Affiliations

  1. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation

    V. A. Mumyatova, G. I. Kozub, T. A. Kondrat’eva, A. A. Terent’ev & N. A. Sanina

  2. Medicinal Chemistry Research and Education Center, Moscow Region State University, 24 ul. Very Voloshinoi, 141014, Mytishchi, Moscow Region, Russian Federation

    V. A. Mumyatova, G. I. Kozub, T. A. Kondrat’eva, A. A. Terent’ev & N. A. Sanina

  3. Department of Fundamental Physical and Chemical Engineering, M. V. Lomonosov Moscow State University, 1 Leninskie Gory, 119991, Moscow, Russian Federation

    A. A. Terent’ev & N. A. Sanina

Authors
  1. V. A. Mumyatova
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  2. G. I. Kozub
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  3. T. A. Kondrat’eva
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  4. A. A. Terent’ev
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  5. N. A. Sanina
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Correspondence to N. A. Sanina.

Additional information

Based on the materials of the Cluster of Conferences InorgChem-2018 (September 17–21, 2018, Astrakhan, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1025–1030, May, 2019.

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Mumyatova, V.A., Kozub, G.I., Kondrat’eva, T.A. et al. Antibacterial activity of [1Fe-2S]- and [2Fe-2S]-nitrosyl complexes as nitric oxide donors. Russ Chem Bull 68, 1025–1030 (2019). https://doi.org/10.1007/s11172-019-2514-3

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  • DOI: https://doi.org/10.1007/s11172-019-2514-3

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