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Naphthoquinone-derived polyol macrolides from natural sources

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Russian Chemical Bulletin Aims and scope

Abstract

New biologically active substances isolated from natural sources provide valuable information on structural motifs that are important for a specific type of activity and can also be used as drugs or serve as raw materials for chemical modification in order to develop new pharmaceuticals. This review considers natural antibiotics combining two pharmacophores in their structure: a redox-active naphthoquinone moiety and a membrane-active polyol macrolide. Data on their structures and the spectrum of biological activity are summarized.

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Authors and Affiliations

  1. Gause Institute of New Antibiotics, 11 ul. Bolshaya Pirogovskaya, 119021, Moscow, Russian Federation

    V. A. Alferova, M. V. Shuvalov, V. A. Korshun & A. P. Tyurin

  2. Department of Chemistry, M. V. Lomonosov Moscow State University, 1, Build. 3, Leninskie Gory, 119991, Moscow, Russian Federation

    M. V. Shuvalov

  3. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 ul. Miklukho-Maklaya, 117997, Moscow, Russian Federation

    V. A. Korshun & A. P. Tyurin

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  1. V. A. Alferova
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  2. M. V. Shuvalov
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  3. V. A. Korshun
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  4. A. P. Tyurin
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Correspondence to A. P. Tyurin.

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Based on the materials of the IV Interdisciplinary Symposium on Medicinal, Organic, Biological Chemistry and Pharmaceutics (MOBI-ChemPharma 2018) (September 23–26, 2018, Novyi Svet, Crimea).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 0955–0966, May, 2019.

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Alferova, V.A., Shuvalov, M.V., Korshun, V.A. et al. Naphthoquinone-derived polyol macrolides from natural sources. Russ Chem Bull 68, 955–966 (2019). https://doi.org/10.1007/s11172-019-2506-3

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  • DOI: https://doi.org/10.1007/s11172-019-2506-3

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