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Russian Chemical Bulletin

, Volume 68, Issue 1, pp 158–162 | Cite as

Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells

  • S. A. Pukhov
  • L. A. Anikina
  • A. A. Larin
  • L. L. Fershtat
  • A. S. Kulikov
  • N. N. MakhovaEmail author
Full Articles

Abstract

Hetarylfuroxans (4-(2-methylpyridin-5-yloxy)-3-phenylfuroxan (1), bis(1,2,4-oxadiazol- 3-yl)furoxan (2), and 4-amino-3-(indenotriazin-3-yl)furoxan (3)) exhibit in vitro cytotoxic activity against chronic myeloid leukemia K562 cells. All studied furoxans induce apoptosis in K562 cells. The experiments with activation of caspases-3 and -7 showed that furoxan 3 possessed the highest apoptosis-inducing capacity. The studied hetarylfuroxans were found to be the promising drug candidates for the treatment of chronic myeloid leukemia K562.

Key words

cytotoxicity chronic myeloid leukemia K562 hetarylfuroxans apoptosis caspase-3 caspase-7 

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Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • S. A. Pukhov
    • 1
  • L. A. Anikina
    • 1
  • A. A. Larin
    • 2
  • L. L. Fershtat
    • 2
  • A. S. Kulikov
    • 2
  • N. N. Makhova
    • 2
    Email author
  1. 1.Institute of Physiologically Active CompoundsRussian Academy of SciencesChernogolovka, Moscow RegionRussian Federation
  2. 2.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussian Federation

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