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Russian Chemical Bulletin

, Volume 68, Issue 2, pp 438–444 | Cite as

Acyl derivatives of ivermectin 5-oxime with antifungal activity

  • E. I. Chernoburova
  • M. A. Shchetinina
  • M. Kh. Dzhafarov
  • V. B. Krylov
  • I. V. ZavarzinEmail author
Full Articles
  • 6 Downloads

Abstract

Acylation of ivermectin 5-oxime was first studied. Procedures for selective acylation of ivermectin 5-oxime either selectively at 5-oxime group or at both 5-oxime group and 4″-hydroxy group to give, respectively, mono- and diacyl derivatives were developed. The synthesized compounds exhibit antifungal activity.

Key words

acyl derivatives of ivermectin 5-oxime ivermectin carboxylic acids acyl chlorides antifungal activity 

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Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • E. I. Chernoburova
    • 1
  • M. A. Shchetinina
    • 1
  • M. Kh. Dzhafarov
    • 1
  • V. B. Krylov
    • 1
  • I. V. Zavarzin
    • 1
    Email author
  1. 1.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussian Federation

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