Russian Chemical Bulletin

, Volume 68, Issue 2, pp 262–269 | Cite as

Mixed systems based on aminated and sulfonated silica nanoparticles: synthesis, self-assembly, and selective adsorption of certain biopolymers

  • L. S. Yakimova
  • A. R. Nugmanova
  • V. G. Evtugyn
  • Yu. N. Osin
  • I. I. StoikovEmail author
Full Articles


Hybrid aminated and sulfonated nanoparticles were synthesized by surface modification of silica nanopowder with 3-aminopropyltriethoxysilane and 1,3-propanesultone, respectively. The developed protocols for the synthesis of three types of "buffer" mixed submicron particles with corresponding ζ-potentials (–21.4±1.3, 4.7±0.4, 12.4±0.8) were based on various methods of nanoprecipitation of synthesized silica nanoparticles modified by amino- and sulfonate groups, and on various conditions of these precepitation (solvent, temperature). Hybrid SiO2 particles, as well as self-assembling associates based on sulfonated and aminated particles, were examined in extraction of biologically important macromolecules. It was established that the efficiency of adsorption of calf thymus DNA increased with increasing zeta potentials of the modified silica particles studied. The interaction of the studied model proteins (bovine serum albumin and lysozyme) with the synthesized silica nanoparticles modified by sulfonate groups increased as the pH of the medium decreased.

Key words

silica surface modification self-assembly self-organization calf thymus DNA bovine serum albumin lyzozyme 


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Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • L. S. Yakimova
    • 1
  • A. R. Nugmanova
    • 1
  • V. G. Evtugyn
    • 2
  • Yu. N. Osin
    • 2
  • I. I. Stoikov
    • 1
    Email author
  1. 1.Kazan Federal University, A. M. Butlerov Chemical InstituteKazanRussian Federation
  2. 2.Kazan Federal University, Interdisciplinary Center Analytical MicroscopyKazanRussian Federation

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