Russian Chemical Bulletin

, Volume 67, Issue 12, pp 2316–2319 | Cite as

Efficient synthesis of 3,4-diarylpyrrole-2-carboxylates, the key fragments of natural antimitotic agents

  • E. A. SilyanovaEmail author
  • A. V. Samet
  • V. V. Semenov
Brief Communications


Barton-Zard reaction of nitrostilbenes with ethyl isocyanoacetate carried out in EtOH in the presence of K2CO3 allowed us to minimize the formation of side products and to obtain 3,4-diarylpyrrole-2-carboxylates in high yields.

Key words

combretastatin analogs lamellarins nitrostilbenes ethyl isocyanoacetate Barton-Zard reaction 3,4-diarylpyrroles 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • E. A. Silyanova
    • 1
    Email author
  • A. V. Samet
    • 1
  • V. V. Semenov
    • 1
  1. 1.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussian Federation

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