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Russian Chemical Bulletin

, Volume 67, Issue 12, pp 2307–2315 | Cite as

The effect of ELOVL6 fatty acid elongase inhibition on the expression of genes associated with the metastasis of breast cancer

  • G. S. Zakharova
  • A. A. PoloznikovEmail author
  • L. A. Astakhova
  • M. P. Raigorodskaya
  • Z. B. Khesina
  • K. A. Fomicheva
  • A. K. Buryak
  • B. Ya. Alekseev
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Abstract

The paper addresses the effect of a new fatty acid elongase 6 (ELOVL6) inhibitor on the migration of breast cancer cells (estrogen receptor positive MCF7 cells and estrogen receptor negative MDA-MB-231 cells) and expression of genes associated with the epithelial-mesenchymal transition, the first stage of tumor metastasis. It was shown that inhibition of the synthesis of C18 fatty acids does not change the migration activity or expression of transcription factors regulating the epithelial-mesenchymal transition. At the same time, the inhibition of ELOVL6 resulted in overexpression of genes associated with breast cancer development and metastasis in vivo (EGFR, CASP4 and VEGFA).

Key words

ELOVL6 inhibitor breast cancer metastasis epithelial-mesenchymal transition EMT MDA-MB-231 MCF7 
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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • G. S. Zakharova
    • 1
  • A. A. Poloznikov
    • 2
    Email author
  • L. A. Astakhova
    • 1
  • M. P. Raigorodskaya
    • 1
  • Z. B. Khesina
    • 1
    • 3
  • K. A. Fomicheva
    • 2
  • A. K. Buryak
    • 3
  • B. Ya. Alekseev
    • 2
  1. 1.SRC Bioclinicum LtdMoscowRussian Federation
  2. 2.National Medical Research Center of RadiologyObninskRussian Federation
  3. 3.A. N. Frumkin Institute of Physical Chemistry and ElectrochemistryRussian Academy of SciencesMoscowRussian Federation

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