Complexation of gallium(III) nitrate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)
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Abstract
Eight dissociation constants of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis (methylene phosphonic acid) (DOTMP, H8L) were determined for the first time by potentiometric titration in water using the CHEMEQUI program. The stability constants of Ga3+ complexes with deprotonated forms of DOTMP were determined. The stability constant of the Ga3+ complex with the fully deprotonated DOTMP ligand, lg KML equal to 27.8, is higher than the corresponding constant for the Ga3+ complex with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), the ligand most widely used in radiopharmacy; it is also higher than the constant for the Ga3+ complex with plasma protein transferrin, which makes the DOTMP ligand very promising for the use in radiopharmacy.
Key words
1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid) gallium(III) potentiometric titration dissociation constant of acid stability constant of metal-ligand complex radiopharmaceuticalsPreview
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References
- 1.F. V. Devyatov, O. V. Bog atyrev, G. I. Zaripova, Russ. Chem. Bull., 2017, 66, 2090.CrossRefGoogle Scholar
- 2.V. E. Baulin, G. S. Tsebr ikova, D. V. Baulin, Y. F. Al Ansary, Biomedical Chemistry: Research and Methods, 2018, 1, e00043.Google Scholar
- 3.R. E. Mewis, S. J. Archib ald, Coord. Chem. Rev., 2010, 254, 1686.CrossRefGoogle Scholar
- 4.R. Delgado, V. Felix, L. M. P. Lima, D. W. Price, Dalton Trans., 2007, 2734.Google Scholar
- 5.E. W. Price, C. Orvig, Chem. Soc. Rev., 2014, 43, 260.CrossRefGoogle Scholar
- 6.P. Spang, C. Herrmann, F. Roesch, Semin. Nucl. Med., 2016, 46, 373.CrossRefGoogle Scholar
- 7.R. Bergmann, M. Meckel, V. Kubícek, J. Pietzsch, J. Steinbach, P. Hermann, F. Rösch, EJNMMI Res., 2016, 6, No. 5, 1.Google Scholar
- 8.T. J. Wadas, E. H. Wong, G. R. Weisman, C. J. Anderson, Chem. Rev., 2010, 110, 2858.CrossRefGoogle Scholar
- 9.N. I. Gorshkov, S. V. Shatik, A. V. Tokarev, I. I. Gavrilova, O. V. Nazarova, A. Yu. Murko, V. D. Krasikov, E. F. Panarin, Russ. Chem. Bull., 2017, 66, 156.CrossRefGoogle Scholar
- 10.M. I. Kabachnik, T. Ya. Medved´, F. I. Belśkii, S. A. Pisareva, Bull. Acad. Sci. USSR, Div. Chem. Sci., 1984, 33, 777.CrossRefGoogle Scholar
- 11.C. F. G. C. Geraldes, A. D. Sherry, W. P. Cacheris, Inorg. Chem., 1989, 28, 3336.CrossRefGoogle Scholar
- 12.R. Delgado, L. C. Siegfried, T. A. Kaden, Helv. Chim. Acta, 1990, 73, 140.CrossRefGoogle Scholar
- 13.R. Delgado, J. Costa, K. P. Guerra, L. M. P. Lima, Pure Appl. Chem., 2005, 77, 569.CrossRefGoogle Scholar
- 14.I. Velikyan, J. Label Compd. Radiopharm., 2015, 58, 99.CrossRefGoogle Scholar
- 15.A. A. Larenkov, G. E. Kodina, A. B. Bruskin, Meditsinskaya radiologiya and radiatsionnaya bezopasnost´ [Medical Radiology and Radiation Safety], 2011, 56, 56 (in Russian).Google Scholar
- 16.G. S. Tsebrikova, V. E. Baulin, I. P. Kalashnikova, V. V. Ragulin, V. O. Zavelśkii, A. Ya. Maruk, A. S. Lunev, O. E. Klement´eva, G. E. Kodina, A. Yu. Tsivadze, Russ. J. Gen. Chem., 2015, 85, 2071.CrossRefGoogle Scholar
- 17.R. P. Baum, F. Rosch, Theranostics, Gallium-68, and Other Radionuclides. A Pathway to Personalized Diagnosis and Treatment, Springer, Heidelberg-New York-Dordrecht-London, 2013, 576 pp.CrossRefGoogle Scholar
- 18.W. R. Harris, L. A. Messori, Coord. Chem. Rev., 2002, 228, 237.CrossRefGoogle Scholar
- 19.W. R. Harris, V. Pecoraro, Bioche mistry, 1983, 22, 292.CrossRefGoogle Scholar
- 20.W. R. Harris, Y. Chen, K. Wein, Inorg. Chem., 1994, 33, 4991.CrossRefGoogle Scholar
- 21.I. Lazar, D. C. Hrncir, W.-D. Kim, G. E. Kiefer, A. D. Sherry, Inorg. Chem., 1992, 31, 4422.CrossRefGoogle Scholar
- 22.V. P. Solov´ev, Programma CHEMEQU Idlya rascheta konstant khimicheskikh ravnovesiy i soputstvuyushchikh parametrov, iskhodya iz eksperimental´nykh rezul´tatov fiziko-khimiches kikh metodov, takikh kak UF-, IK- i YAMR-spektroskopiya, kalorimetriya, potentsiometriya i konduktometriya [CHEMEQUI Program for Computations of Equilibrium Constants and Related Quantitiess from Experimental Results of UV-Vis, IR, and NMR Spectroscopy, Calorimetry, Potentiometry, and Conductometry] (in Russian); http://vpsolovev.ru/programs/ (Novem ber 24, 2018).
- 23.V. P. Solov´ev, A. Y. Tsivadze, Prot. Met. Phys. Chem. Surf., 2015, 51, 1.CrossRefGoogle Scholar
- 24.P. H. Muller, P. Neumann, R. Storm, Tafeln der mathematischen Statistik, VEB Fachbuchverlag, Leipzig, 1979.Google Scholar
- 25.A. E. Martell, R. J. Motekaitis, E. T. Clarke, R. Delgado, Y. Sun, R. Ma, Supramol. Chem., 1996, 6, 353.CrossRefGoogle Scholar
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