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Russian Chemical Bulletin

, Volume 67, Issue 12, pp 2184–2187 | Cite as

Complexation of gallium(III) nitrate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)

  • G. S. TsebrikovaEmail author
  • R. T. Barsamian
  • V. P. Solov´ev
  • Z. A. Kudryashova
  • V. E. Baulin
  • Y. J. Wang
  • A. Yu. Tsivadze
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Abstract

Eight dissociation constants of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis (methylene phosphonic acid) (DOTMP, H8L) were determined for the first time by potentiometric titration in water using the CHEMEQUI program. The stability constants of Ga3+ complexes with deprotonated forms of DOTMP were determined. The stability constant of the Ga3+ complex with the fully deprotonated DOTMP ligand, lg KML equal to 27.8, is higher than the corresponding constant for the Ga3+ complex with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), the ligand most widely used in radiopharmacy; it is also higher than the constant for the Ga3+ complex with plasma protein transferrin, which makes the DOTMP ligand very promising for the use in radiopharmacy.

Key words

1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid) gallium(III) potentiometric titration dissociation constant of acid stability constant of metal-ligand complex radiopharmaceuticals 
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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • G. S. Tsebrikova
    • 1
    Email author
  • R. T. Barsamian
    • 2
  • V. P. Solov´ev
    • 1
  • Z. A. Kudryashova
    • 1
    • 2
  • V. E. Baulin
    • 1
    • 3
  • Y. J. Wang
    • 4
  • A. Yu. Tsivadze
    • 1
  1. 1.Frumkin Institute of Physical Chemistry and ElectrochemistryRussian Academy of SciencesMoscowRussian Federation
  2. 2.Russian Technological University, Lomonosov Moscow State University of Fine Chemical TechnologiesMoscowRussian Federation
  3. 3.Institute of Physiologically Active CompoundsRussian Academy of SciencesChernogolovkaRussian Federation
  4. 4.School of Materials Science and EngineeringHarbin Institute of TechnologyHarbinChina

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