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Russian Chemical Bulletin

, Volume 67, Issue 11, pp 2079–2087 | Cite as

Synthesis and biological activity of 3-guanidino-6-R-imidazo[1,2-b]- and 6-guanidino-3-R-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines

  • R. I. IshmetovaEmail author
  • N. K. Ignatenko
  • A. V. Korotina
  • I. N. Ganebnykh
  • P. A. Slepukhin
  • V. A. Babkova
  • N. A. Gerasimova
  • N. P. Evstigneeva
  • N. V. Zilberberg
  • N. V. Kungurov
  • G. L. Rusinov
  • A. A. Spasov
  • O. N. Chupakhin
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Abstract

The reaction of azoloannulated [1,2,4,5]tetrazines with guanidine was studied. New 3-guanidinoimidazo[1,2-b]- and 6-guanidino[1,2,4]triazolo[4,3-b] [1,2,4,5]tetrazines were synthesized using the nucleophilic substitution methodology. Compounds with high antibacterial and antiglycation activity were revealed.

Key words

1,2,4,5-tetrazines imidazo[1,2-b][1,2,4,5]tetrazines [1,2,4]triazolo[4,3-b]- [1,2,4,5] tetrazines guanidine nucleophilic substitution antiglycation activity antibacterial activity 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • R. I. Ishmetova
    • 1
    Email author
  • N. K. Ignatenko
    • 1
  • A. V. Korotina
    • 1
  • I. N. Ganebnykh
    • 1
  • P. A. Slepukhin
    • 1
    • 2
  • V. A. Babkova
    • 3
  • N. A. Gerasimova
    • 4
  • N. P. Evstigneeva
    • 4
  • N. V. Zilberberg
    • 4
  • N. V. Kungurov
    • 4
  • G. L. Rusinov
    • 1
    • 2
  • A. A. Spasov
    • 3
  • O. N. Chupakhin
    • 1
    • 2
  1. 1.I. Ya. Postovsky Institute of Organic SynthesisUral Branch of the Russian Academy of SciencesYekaterinburgRussian Federation
  2. 2.Ural Federal University named after the first President of Russia B. N. YeltsinYekaterinburgRussian Federation
  3. 3.Volgograd State Medical UniversityMinistry of Health of the Russian FederationVolgogradRussian Federation
  4. 4.Ural Research Institute of Dermatovenereology and ImmunopathologyYekaterinburgRussian Federation

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