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Russian Chemical Bulletin

, Volume 67, Issue 11, pp 1992–1996 | Cite as

Mixed systems based on the cationic surfactant with a butyl carbamate fragment and nonionic surfactant Tween 80: Aggregation behavior and solubilization properties

  • A. B. MirgorodskayaEmail author
  • R. A. Kushnazarova
  • A. Yu. Shcherbakov
  • S. S. Lukashenko
  • N. A. Zhukova
  • V. A. Mamedov
  • L. Ya. Zakharova
  • O. G. Sinyashin
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Abstract

Mixed micelles are formed in the binary compositions based on the cationic surfactant functionalized by the butyl carbamate fragment and nonionic surfactant Tween 80 in aqueous solutions. The aggregation parameters of the formed micelles (critical micelle concentration, size, and surface potential) depend on the component ratio in the system. The solubilization effect of individual and mixed micelles on the drugs of the heterocyclic series, indomethacin and 1-[5-(4-chlorophenyl)-3-phenylpyrrol-2-yl)]benzimidazol-2(3H)-one, was quantitatively characterized.

Key words

surfactants aggregation mixed micelles solubilization drugs 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • A. B. Mirgorodskaya
    • 1
    Email author
  • R. A. Kushnazarova
    • 1
  • A. Yu. Shcherbakov
    • 1
  • S. S. Lukashenko
    • 1
  • N. A. Zhukova
    • 1
  • V. A. Mamedov
    • 1
    • 2
  • L. Ya. Zakharova
    • 1
    • 2
  • O. G. Sinyashin
    • 2
  1. 1.A. E. Arbuzov Institute of Organic and Physical Chemistry – Subdivision of the Federal Reseach Center “Kazan Scientific Center of the Russian Academy of Sciences,”KazanRussian Federation
  2. 2.Kazan National Research Technological UniversityKazanRussian Federation

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