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Russian Chemical Bulletin

, Volume 67, Issue 11, pp 1955–1970 | Cite as

2H-Benzimidazole N-oxides: synthesis, chemical properties, and biological activity

  • E. A. ChugunovaEmail author
  • V. A. Samsonov
  • A. S. Gazizov
  • A. R. Burilov
  • M. A. Pudovik
  • O. G. Sinyashin
Reviews
  • 15 Downloads

Abstract

The review presents and summarizes comprehensive data starting from 2006 on the synthesis of mono- and di-N-oxides of 2H-benzimidazoles and their chemical properties. Especial attention was paid to the chemical transformations of 2H-benzimidazole 1,3-dioxides upon heating to give 3H-2,1,4-benzoxadiazine 4-oxides and 2H-benzimidazole mono-N-oxides. The biological activity of compounds was covered.

Key words

2H-benzimidazole 1,3-dioxide 2H-benzimidazole mono-N-oxide 3H-2,1,4- benzoxadiazine 4-oxide benzofuroxan "hybrid" compounds Trypanosoma cruzi 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • E. A. Chugunova
    • 1
    Email author
  • V. A. Samsonov
    • 2
  • A. S. Gazizov
    • 1
  • A. R. Burilov
    • 1
  • M. A. Pudovik
    • 1
  • O. G. Sinyashin
    • 1
  1. 1.A. E. Arbuzov Institute of Organic and Physical ChemistryKazan Scientific Center of the Russian Academy of SciencesKazanRussian Federation
  2. 2.N. N. Vorozhtsov Novosibirsk Institute of Organic ChemistrySiberian Branch of the Russian Academy of SciencesNovosibirskRussian Federation

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