Advertisement

Russian Chemical Bulletin

, Volume 67, Issue 4, pp 774–778 | Cite as

Complex 69mZnLigCl2 (Lig is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide) as a potential radiopharmaceutical

  • M. A. Orlova
  • T. P. Trofimova
  • A. P. Orlov
  • I. A. Ivanov
  • A. V. Severin
  • G. Yu. Aleshin
  • S. S. Belyshev
  • A. N. Vasiliev
  • S. N. Kalmykov
Full Article
  • 14 Downloads

Abstract

The cytotoxicity of complex 69mZnLigCl2 (Lig is N-(5,6-dihydro-4H-1,3-thiazin-2-yl) benzamide) against the K-562 cell line (chronic myeloid leukemia) was considered in comparison with the cells of healthy donors. The 69mZnLigCl2 complex was obtained and characterized by TLC and autoradiography methods. The kinetics of zinc sorption on hydroxyapatite was studied.

Key words

69mZn isotope dihydrothiazine derivatives hydroxyapatite K-562 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    T. L. Rosenblat, M. R. McDevitt, D. A. Mulford, N. Pandit-Taskar, C. R. Divqi, K. S. Panageas, M. L. Htaney, S. Morgenstem, A. Sgouros, S. M. Larson, D. A. Scheinberg, J. G. Jurcic, Clin. Cancer Res., 2010, 16, 5303.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    J. G. Jurcic, S. M. Larson, G. Sgouros, M. R. McDevitt, R. D. Finn, Blood, 2002, 100, 1233.PubMedGoogle Scholar
  3. 3.
    M. Miederer, M. R. McDevitt, G. Sgouros, K. Kramer, N. K. Cheung, D. A. Scheinberg, J. Nucl. Med., 2004, 45,129.PubMedGoogle Scholar
  4. 4.
    V. I. Chernov, O. D. Bragina, I. G. Sinilkin, A. A. Medvedeva, R. V. Zel´chan, Vestn. Rentgenologii i Radiologii [Rontgenology and Radiology Bulletin], 2016, 97, 306 (in Russian).CrossRefGoogle Scholar
  5. 5.
    M. R. McDevitt, D. Ma, J. Simon, R. K. Frank, D. A. Scheinberg, Appl. Radiat. Isot., 2002, 57,841.CrossRefPubMedGoogle Scholar
  6. 6.
    M. A. Orlova, T. P. Trofimova, R. A. Aliev, A. P. Orlov, S. V. Nikulin, A. N. Proshin, S. N. Kalmykov. J. Radioanal. Nucl. Chem., 2017, 311, 1177.CrossRefGoogle Scholar
  7. 7.
    A. P. Orlov, T. P. Trofimova, E. Yu. Osipova, A. N. Proshin, M. A. Orlova, Russ. Chem. Bull., 2017, 66, 1860.CrossRefGoogle Scholar
  8. 8.
    M. Molokhia, G. Sturniolo, R. Shields, L. A. Turnberg, Am. J. Clin. Nutr., 1980, 33,881.CrossRefPubMedGoogle Scholar
  9. 9.
    H. T. Wolterbeek, A. J. M. van der Meer, Sci. Total Envir., 2002, 287,13.CrossRefGoogle Scholar
  10. 10.
    A. Takeda, H. Tamano, N. Oku, Brain Res., 2003, 965,170.CrossRefPubMedGoogle Scholar
  11. 11.
    A. V. Severin, M. A. Orlova, E. S. Shalamova, T. P. Trofimova, I. A. Ivanov, Russ. Chem. Bull., 2017, 66,9.CrossRefGoogle Scholar
  12. 12.
    M. A. Orlova, T. P. Trofimova, S. V. Nikulin, A. P. Orlov, Mosc. Univ. Chem. Bull., 2016, 71,258.CrossRefGoogle Scholar
  13. 13.
    R. A. Aliev, G. Yu. Aleshin, S. S. Belyshev, B. S. Ishhanov, A. B. Priselkova, V. V. Hankin, V. Yu. Pozharskaya, M. A. Orlova, S. N. Kalmykov, Russ. Chem. Bull., 2017, 66,368.CrossRefGoogle Scholar
  14. 14.
    S. Schweizer, Phys. Stat. Sol. (a), 2001, 187,335.CrossRefGoogle Scholar
  15. 15.
    A. J. P. Veerman, R. Pieters, Br. J. Haematol., 1990, 74,381.CrossRefPubMedGoogle Scholar
  16. 16.
    A. P. Orlov, M. A. Orlova, T. P. Trofimova, E. Yu. Osipova, A. N. Proshin, Russ. Chem. Bull., 2016, 65, 1879.CrossRefGoogle Scholar
  17. 17.
    M. A. Orlova, E. Yu. Osipova, S. A. Rumyantsev, S. P. Ashurko, Russ. Chem. Bull., 2012, 61,405.CrossRefGoogle Scholar
  18. 18.
    X. Yu plng, W. Franklln, Environ. Sci. Technol., 1994, 28, 1472.CrossRefGoogle Scholar
  19. 19.
    M. Motskin, D. M. Wright, K. Muller, N. Kyle, T. G. Gard, A. E. Porter, J. N. Skepper, Biomaterials, 2009, 30, 3307.CrossRefPubMedGoogle Scholar
  20. 20.
    A. Corami, S. Mignardi, V. Ferrini, J. Hazardous Mater., 2007, 146,164.CrossRefGoogle Scholar
  21. 21.
    S. Meski, S. Ziani, H. Khireddine, S. Boudboub, J. Hazardous Mater., 2011, 186, 1007.CrossRefGoogle Scholar
  22. 22.
    Z. Elouear, J. Bouzid, N. Boujelben, M. Feki, F. Jamoussi, A. Montiel, J. Hazardous Mater., 2008, 156, 412.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • M. A. Orlova
    • 1
    • 2
  • T. P. Trofimova
    • 1
    • 3
  • A. P. Orlov
    • 1
  • I. A. Ivanov
    • 1
  • A. V. Severin
    • 1
  • G. Yu. Aleshin
    • 1
  • S. S. Belyshev
    • 4
  • A. N. Vasiliev
    • 1
  • S. N. Kalmykov
    • 1
    • 5
  1. 1.Chemical DepartmentM. V. Lomonosov Moscow State UniversityMoscow, Russian FederationRussia
  2. 2.Dmitry Rogachev National Medical Scientific Center of Pediatric Hematology, Oncology, and ImmunologyMoscow, Russian FederationRussia
  3. 3.Institute of Physiologically Active CompoundsRussian Academy of SciencesChernogolovka, Moscow Region, Russian FederationRussia
  4. 4.D. V. Skobel’tsyn Research Institute of Nuclear PhysicsM. V. Lomonosov Moscow State UniversityMoscow, Russian FederationRussia
  5. 5.National Research Center “Kurchatov Institute,”Moscow, Russian FederationRussia

Personalised recommendations