Russian Chemical Bulletin

, Volume 67, Issue 4, pp 774–778 | Cite as

Complex 69mZnLigCl2 (Lig is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide) as a potential radiopharmaceutical

  • M. A. OrlovaEmail author
  • T. P. Trofimova
  • A. P. Orlov
  • I. A. Ivanov
  • A. V. Severin
  • G. Yu. Aleshin
  • S. S. Belyshev
  • A. N. Vasiliev
  • S. N. Kalmykov
Full Article


The cytotoxicity of complex 69mZnLigCl2 (Lig is N-(5,6-dihydro-4H-1,3-thiazin-2-yl) benzamide) against the K-562 cell line (chronic myeloid leukemia) was considered in comparison with the cells of healthy donors. The 69mZnLigCl2 complex was obtained and characterized by TLC and autoradiography methods. The kinetics of zinc sorption on hydroxyapatite was studied.

Key words

69mZn isotope dihydrothiazine derivatives hydroxyapatite K-562 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • M. A. Orlova
    • 1
    • 2
    Email author
  • T. P. Trofimova
    • 1
    • 3
  • A. P. Orlov
    • 1
  • I. A. Ivanov
    • 1
  • A. V. Severin
    • 1
  • G. Yu. Aleshin
    • 1
  • S. S. Belyshev
    • 4
  • A. N. Vasiliev
    • 1
  • S. N. Kalmykov
    • 1
    • 5
  1. 1.Chemical DepartmentM. V. Lomonosov Moscow State UniversityMoscow, Russian FederationRussia
  2. 2.Dmitry Rogachev National Medical Scientific Center of Pediatric Hematology, Oncology, and ImmunologyMoscow, Russian FederationRussia
  3. 3.Institute of Physiologically Active CompoundsRussian Academy of SciencesChernogolovka, Moscow Region, Russian FederationRussia
  4. 4.D. V. Skobel’tsyn Research Institute of Nuclear PhysicsM. V. Lomonosov Moscow State UniversityMoscow, Russian FederationRussia
  5. 5.National Research Center “Kurchatov Institute,”Moscow, Russian FederationRussia

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