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Russian Chemical Bulletin

, Volume 67, Issue 4, pp 743–746 | Cite as

Multicomponent reactions in the synthesis of dihydropyrimidine-containing podands having tuberculostatic activity

  • O. V. Fedorova
  • E. S. Filatova
  • Yu. A. Titova
  • M. A. Kravchenko
  • I. D. Medvinskiy
  • G. L. Rusinov
  • V. N. Charushin
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Abstract

Dihydropyrimidinethione podands, as well as podands containing 2-thienyl substituents have been synthesized via the multicomponent Biginelli reaction. Tuberculostatic activity of the novel podands was shown to depend on the polyether unit length. In particular, activity of dihydropyrimidinethione podands against laboratory strains of Mycobacterium tuberculosis, H37Rv, M. avium, M. terrae, and the clinical strain of multi-drug resistant M. tuberculosis (MDR), increases with a shortening of the polyether unit length.

Key words

dihydropyrimidine-containing podands the Biginelli reaction tuberculostatic activity typical and atypical mycobacterial strains 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • O. V. Fedorova
    • 1
  • E. S. Filatova
    • 1
    • 2
  • Yu. A. Titova
    • 1
  • M. A. Kravchenko
    • 3
  • I. D. Medvinskiy
    • 3
  • G. L. Rusinov
    • 1
    • 2
  • V. N. Charushin
    • 1
    • 2
  1. 1.Postovsky Institute of Organic SynthesisUral Branch of the Russian Academy of SciencesEkaterinburg, Russian FederationRussia
  2. 2.Ural Federal University named after the first President of Russia B. N. YeltsinEkaterinburg, Russian FederationRussia
  3. 3.Ural Research Institute of PhthisiopulmonologyMinistry of Health of the Russian FederationEkaterinburg, Russian FederationRussia

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